DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin

Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cyste...

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Bibliographic Details
Main Authors: Deshpande, Megha Subhash, Junedi, Sendy, Prakash, Halan, Nagao, Satoshi, Yamanaka, Masaru, Hirota, Shun
Format: Article in Journal/Newspaper
Language:English
Published: The Royal Society of Chemistry 2014
Subjects:
Sperm whale
Online Access:http://hdl.handle.net/10061/10414
Description
Summary:Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cysteine to the heme.

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