Cardiac disease in renal transplant recipients

Thesis (M.Sc.)--Memorial University of Newfoundland, 2001. Medicine Bibliography: leaves 95-112 Cardiac disease (CVD) is a major cause of morbidity in renal transplant recipients (RTR). The relative importance of traditional vs. transplant-related risk factors, however, remains controversial, while...

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Bibliographic Details
Main Author: Rigatto, Claudio, 1965-
Other Authors: Memorial University of Newfoundland. Faculty of Medicine
Format: Thesis
Language:English
Published: 2001
Subjects:
Online Access:http://collections.mun.ca/cdm/ref/collection/theses3/id/96014
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spelling ftmemorialunivdc:oai:collections.mun.ca:theses3/96014 2023-05-15T17:23:32+02:00 Cardiac disease in renal transplant recipients Rigatto, Claudio, 1965- Memorial University of Newfoundland. Faculty of Medicine 2001 viii, 112 leaves : ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses3/id/96014 eng eng Electronic Theses and Dissertations (11.37 MB) -- http://collections.mun.ca/PDFs/theses/Rigatto_Claudio.pdf a1539250 http://collections.mun.ca/cdm/ref/collection/theses3/id/96014 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Kidneys--Transplantation Heart--Diseases Kidney Transplantation Cardiovascular Diseases Hypertrophy Left Ventricular Text Electronic thesis or dissertation 2001 ftmemorialunivdc 2015-08-06T19:18:54Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2001. Medicine Bibliography: leaves 95-112 Cardiac disease (CVD) is a major cause of morbidity in renal transplant recipients (RTR). The relative importance of traditional vs. transplant-related risk factors, however, remains controversial, while the impact of LV disorders has not been well studied. We conducted two cohort studies to examine the incidence, determinants, and outcomes of LV disorders in RTR, and to compare the relative importance of traditional vs. transplant-related risk factors. In Study One (sequential echocardiograms in a prospective cohort of RTR), LV hypertrophy regressed over the first two post transplant years and thereafter remained stable. Older age and hypertension predicted failure to regress. In Study Two (a retrolective cohort study of 473 RTR), congestive heart failure (CHF) was as common and as adverse a morbid event as ischemic heart disease (MD). Age, diabetes, gender, blood pressure and anemia were the dominant predictors of CHF, while age, diabetes, gender, blood pressure and cholesterol were the dominant risk factors for MD. The determinants of de novo MD in RTR were similar to those in general population, whereas the determinants of LV disorders are similar to those in chronic renal insufficiency. Transplant associated variables, with the exception of anemia, were not strongly associated with outcomes. -- Key Words: Renal transplantation, left ventricular hypertrophy, cardiovascular disease, anemia, cohort study. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI)
institution Open Polar
collection Memorial University of Newfoundland: Digital Archives Initiative (DAI)
op_collection_id ftmemorialunivdc
language English
topic Kidneys--Transplantation
Heart--Diseases
Kidney Transplantation
Cardiovascular Diseases
Hypertrophy
Left Ventricular
spellingShingle Kidneys--Transplantation
Heart--Diseases
Kidney Transplantation
Cardiovascular Diseases
Hypertrophy
Left Ventricular
Rigatto, Claudio, 1965-
Cardiac disease in renal transplant recipients
topic_facet Kidneys--Transplantation
Heart--Diseases
Kidney Transplantation
Cardiovascular Diseases
Hypertrophy
Left Ventricular
description Thesis (M.Sc.)--Memorial University of Newfoundland, 2001. Medicine Bibliography: leaves 95-112 Cardiac disease (CVD) is a major cause of morbidity in renal transplant recipients (RTR). The relative importance of traditional vs. transplant-related risk factors, however, remains controversial, while the impact of LV disorders has not been well studied. We conducted two cohort studies to examine the incidence, determinants, and outcomes of LV disorders in RTR, and to compare the relative importance of traditional vs. transplant-related risk factors. In Study One (sequential echocardiograms in a prospective cohort of RTR), LV hypertrophy regressed over the first two post transplant years and thereafter remained stable. Older age and hypertension predicted failure to regress. In Study Two (a retrolective cohort study of 473 RTR), congestive heart failure (CHF) was as common and as adverse a morbid event as ischemic heart disease (MD). Age, diabetes, gender, blood pressure and anemia were the dominant predictors of CHF, while age, diabetes, gender, blood pressure and cholesterol were the dominant risk factors for MD. The determinants of de novo MD in RTR were similar to those in general population, whereas the determinants of LV disorders are similar to those in chronic renal insufficiency. Transplant associated variables, with the exception of anemia, were not strongly associated with outcomes. -- Key Words: Renal transplantation, left ventricular hypertrophy, cardiovascular disease, anemia, cohort study.
author2 Memorial University of Newfoundland. Faculty of Medicine
format Thesis
author Rigatto, Claudio, 1965-
author_facet Rigatto, Claudio, 1965-
author_sort Rigatto, Claudio, 1965-
title Cardiac disease in renal transplant recipients
title_short Cardiac disease in renal transplant recipients
title_full Cardiac disease in renal transplant recipients
title_fullStr Cardiac disease in renal transplant recipients
title_full_unstemmed Cardiac disease in renal transplant recipients
title_sort cardiac disease in renal transplant recipients
publishDate 2001
url http://collections.mun.ca/cdm/ref/collection/theses3/id/96014
genre Newfoundland studies
University of Newfoundland
genre_facet Newfoundland studies
University of Newfoundland
op_source Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
op_relation Electronic Theses and Dissertations
(11.37 MB) -- http://collections.mun.ca/PDFs/theses/Rigatto_Claudio.pdf
a1539250
http://collections.mun.ca/cdm/ref/collection/theses3/id/96014
op_rights The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
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