| Summary: | Thesis (M.Sc.)--Memorial University of Newfoundland, 2001. Medicine Bibliography: leaves 95-112 Cardiac disease (CVD) is a major cause of morbidity in renal transplant recipients (RTR). The relative importance of traditional vs. transplant-related risk factors, however, remains controversial, while the impact of LV disorders has not been well studied. We conducted two cohort studies to examine the incidence, determinants, and outcomes of LV disorders in RTR, and to compare the relative importance of traditional vs. transplant-related risk factors. In Study One (sequential echocardiograms in a prospective cohort of RTR), LV hypertrophy regressed over the first two post transplant years and thereafter remained stable. Older age and hypertension predicted failure to regress. In Study Two (a retrolective cohort study of 473 RTR), congestive heart failure (CHF) was as common and as adverse a morbid event as ischemic heart disease (MD). Age, diabetes, gender, blood pressure and anemia were the dominant predictors of CHF, while age, diabetes, gender, blood pressure and cholesterol were the dominant risk factors for MD. The determinants of de novo MD in RTR were similar to those in general population, whereas the determinants of LV disorders are similar to those in chronic renal insufficiency. Transplant associated variables, with the exception of anemia, were not strongly associated with outcomes. -- Key Words: Renal transplantation, left ventricular hypertrophy, cardiovascular disease, anemia, cohort study.
|
|---|