Sudden Cardiac Death (SCD) in the young (2y-50y) in Newfoundland & Labrador: 2009-2013
Sudden cardiac death (SCD) in young people is a catastrophic event, in which many productive life-years are lost and often has a genetic etiology. Several recurrent mutations (due to founder effect) in multiple genes which cause SCD, have been identified in Newfoundland and Labrador population. In t...
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| Format: | Thesis |
| Language: | English |
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Memorial University of Newfoundland
2017
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| Online Access: | https://research.library.mun.ca/12520/ https://research.library.mun.ca/12520/1/thesis.pdf |
| Summary: | Sudden cardiac death (SCD) in young people is a catastrophic event, in which many productive life-years are lost and often has a genetic etiology. Several recurrent mutations (due to founder effect) in multiple genes which cause SCD, have been identified in Newfoundland and Labrador population. In this project, all cases (2y-50y) reported to the Medical Examiner office between the years (2009-2013) inclusive were ascertained, and classified into SCDs and non-SCDs by the research team based on several pre-specified contributing factors. A total of 174 out of 545 Medical Examiner cases fulfilled the SCD criteria. The overall reported incidence of SCD was 11 per 100,000 person-years, the incidence increased with age and the majority of cases observed in men. By comparing our result with the reported incidence worldwide, a higher incidence was detected. Further studies in SCD project will investigate the genetic and non-genetic implications of SCD in Newfoundland and Labrador. |
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