p53: From Fundamental Biology to Clinical Applications in Cancer
p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mito...
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ftmdpi:oai:mdpi.com:/2079-7737/11/9/1325/ 2023-08-20T04:05:47+02:00 p53: From Fundamental Biology to Clinical Applications in Cancer Maurizio Capuozzo Mariachiara Santorsola Marco Bocchetti Francesco Perri Marco Cascella Vincenza Granata Venere Celotto Oreste Gualillo Alessia Maria Cossu Guglielmo Nasti Michele Caraglia Alessandro Ottaiano agris 2022-09-06 application/pdf https://doi.org/10.3390/biology11091325 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/biology11091325 https://creativecommons.org/licenses/by/4.0/ Biology; Volume 11; Issue 9; Pages: 1325 p53 tp53 cancer DNA repair tumour progression Text 2022 ftmdpi https://doi.org/10.3390/biology11091325 2023-08-01T06:22:37Z p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mitochondrial function, global regulation of gene expression, miRNAs, etc. Its crucial importance is denounced by the high percentage of amino acid sequence identity between very different species (Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Danio rerio, Canis lupus familiaris, Gekko japonicus). Many of its activities allowed life on Earth (e.g., repair from radiation-induced DNA damage) and directly contribute to its tumour suppressor function. In this review, we provide paramount information on p53, from its discovery, which is an interesting paradigm of science evolution, to potential clinical applications in anti-cancer treatment. The description of the fundamental biology of p53 is enriched by specific information on the structure and function of the protein as well by tumour/host evolutionistic perspectives of its role. Text Canis lupus MDPI Open Access Publishing Biology 11 9 1325 |
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p53 tp53 cancer DNA repair tumour progression |
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p53 tp53 cancer DNA repair tumour progression Maurizio Capuozzo Mariachiara Santorsola Marco Bocchetti Francesco Perri Marco Cascella Vincenza Granata Venere Celotto Oreste Gualillo Alessia Maria Cossu Guglielmo Nasti Michele Caraglia Alessandro Ottaiano p53: From Fundamental Biology to Clinical Applications in Cancer |
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p53 tp53 cancer DNA repair tumour progression |
description |
p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mitochondrial function, global regulation of gene expression, miRNAs, etc. Its crucial importance is denounced by the high percentage of amino acid sequence identity between very different species (Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Danio rerio, Canis lupus familiaris, Gekko japonicus). Many of its activities allowed life on Earth (e.g., repair from radiation-induced DNA damage) and directly contribute to its tumour suppressor function. In this review, we provide paramount information on p53, from its discovery, which is an interesting paradigm of science evolution, to potential clinical applications in anti-cancer treatment. The description of the fundamental biology of p53 is enriched by specific information on the structure and function of the protein as well by tumour/host evolutionistic perspectives of its role. |
format |
Text |
author |
Maurizio Capuozzo Mariachiara Santorsola Marco Bocchetti Francesco Perri Marco Cascella Vincenza Granata Venere Celotto Oreste Gualillo Alessia Maria Cossu Guglielmo Nasti Michele Caraglia Alessandro Ottaiano |
author_facet |
Maurizio Capuozzo Mariachiara Santorsola Marco Bocchetti Francesco Perri Marco Cascella Vincenza Granata Venere Celotto Oreste Gualillo Alessia Maria Cossu Guglielmo Nasti Michele Caraglia Alessandro Ottaiano |
author_sort |
Maurizio Capuozzo |
title |
p53: From Fundamental Biology to Clinical Applications in Cancer |
title_short |
p53: From Fundamental Biology to Clinical Applications in Cancer |
title_full |
p53: From Fundamental Biology to Clinical Applications in Cancer |
title_fullStr |
p53: From Fundamental Biology to Clinical Applications in Cancer |
title_full_unstemmed |
p53: From Fundamental Biology to Clinical Applications in Cancer |
title_sort |
p53: from fundamental biology to clinical applications in cancer |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/biology11091325 |
op_coverage |
agris |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Biology; Volume 11; Issue 9; Pages: 1325 |
op_relation |
https://dx.doi.org/10.3390/biology11091325 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/biology11091325 |
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Biology |
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11 |
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9 |
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1325 |
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