Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedit...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Alfredo Braña, Aida Sarmiento-Vizcaíno, Miguel Osset, Ignacio Pérez-Victoria, Jesús Martín, Nuria De Pedro, Mercedes De la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis García, Gloria Blanco
Format: Text
Language:English
Published: Multidisciplinary Digital Publishing Institute 2017
Subjects:
lobophorins
spirotetronate antibiotic
Streptomyces
antitumor
Cantabrian Sea-derived actinobacteria
Lophelia pertusa
Online Access:https://doi.org/10.3390/md15050144
Description
Summary:The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.

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