New Benzoxazine Secondary Metabolites from an Arctic Actinomycete
Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and...
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ftmdpi:oai:mdpi.com:/1660-3397/12/5/2526/ 2023-08-20T04:03:45+02:00 New Benzoxazine Secondary Metabolites from an Arctic Actinomycete Kyuho Moon Chan-Hong Ahn Yoonho Shin Tae Won Keebeom Ko Sang Lee Ki-Bong Oh Jongheon Shin Seung-Il Nam Dong-Chan Oh agris 2014-04-30 application/pdf https://doi.org/10.3390/md12052526 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/md12052526 https://creativecommons.org/licenses/by/3.0/ Marine Drugs; Volume 12; Issue 5; Pages: 2526-2538 Arctic marine actinomycete secondary metabolite benzoxazine C-1027 fijiolides disaccharide isocitrate lyase Text 2014 ftmdpi https://doi.org/10.3390/md12052526 2023-07-31T20:37:06Z Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively. Text Arctic MDPI Open Access Publishing Arctic Marine Drugs 12 5 2526 2538 |
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Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Arctic marine actinomycete secondary metabolite benzoxazine C-1027 fijiolides disaccharide isocitrate lyase |
spellingShingle |
Arctic marine actinomycete secondary metabolite benzoxazine C-1027 fijiolides disaccharide isocitrate lyase Kyuho Moon Chan-Hong Ahn Yoonho Shin Tae Won Keebeom Ko Sang Lee Ki-Bong Oh Jongheon Shin Seung-Il Nam Dong-Chan Oh New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
topic_facet |
Arctic marine actinomycete secondary metabolite benzoxazine C-1027 fijiolides disaccharide isocitrate lyase |
description |
Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively. |
format |
Text |
author |
Kyuho Moon Chan-Hong Ahn Yoonho Shin Tae Won Keebeom Ko Sang Lee Ki-Bong Oh Jongheon Shin Seung-Il Nam Dong-Chan Oh |
author_facet |
Kyuho Moon Chan-Hong Ahn Yoonho Shin Tae Won Keebeom Ko Sang Lee Ki-Bong Oh Jongheon Shin Seung-Il Nam Dong-Chan Oh |
author_sort |
Kyuho Moon |
title |
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
title_short |
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
title_full |
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
title_fullStr |
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
title_full_unstemmed |
New Benzoxazine Secondary Metabolites from an Arctic Actinomycete |
title_sort |
new benzoxazine secondary metabolites from an arctic actinomycete |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2014 |
url |
https://doi.org/10.3390/md12052526 |
op_coverage |
agris |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Marine Drugs; Volume 12; Issue 5; Pages: 2526-2538 |
op_relation |
https://dx.doi.org/10.3390/md12052526 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.3390/md12052526 |
container_title |
Marine Drugs |
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12 |
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5 |
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2526 |
op_container_end_page |
2538 |
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