New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and...

Full description

Bibliographic Details
Published in:Marine Drugs
Main Authors: Kyuho Moon, Chan-Hong Ahn, Yoonho Shin, Tae Won, Keebeom Ko, Sang Lee, Ki-Bong Oh, Jongheon Shin, Seung-Il Nam, Dong-Chan Oh
Format: Text
Language:English
Published: Multidisciplinary Digital Publishing Institute 2014
Subjects:
Arctic
marine actinomycete
secondary metabolite
benzoxazine
C-1027
fijiolides
disaccharide
isocitrate lyase
Online Access:https://doi.org/10.3390/md12052526
Description
Summary:Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC50 values of 0.9 and 2.7 μM, respectively.

Similar Items