A Review: Meridianins and Meridianins Derivatives

Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacologica...

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Bibliographic Details
Published in:Molecules
Main Author: Linxia Xiao
Format: Text
Language:English
Published: Multidisciplinary Digital Publishing Institute 2022
Subjects:
meridianins
indole alkaloids
biological activities
pharmacological applications
pharmacokinetic characters
chemical synthesis
prospects
Antarctic
Antarc*
Online Access:https://doi.org/10.3390/molecules27248714
Description
Summary:Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacological applications, pharmacokinetic characters and chemical synthesis of meridianins and their derivatives. And prospects on discovering new bioactivities of meridianins and optimizing their structure for the improvement of the ADMET properties are provided.

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