Circulating sclerostin associated with vertebral bone marrow fat in older men but not women.

CONTEXT: Osteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relation...

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Bibliographic Details
Main Authors: Ma, Yu-Heng Vivian, Schwartz, Ann V, Sigurdsson, Sigurdur, Hue, Trisha F, Lang, Thomas F, Harris, Tamara B, Rosen, Clifford J, Vittinghoff, Eric, Eiriksdottir, Gudny, Hauksdottir, Alda M, Siggeirsdottir, Kristin, Sigurdsson, Gunnar, Oskarsdottir, Diana, Napoli, Nicola, Palermo, Lisa, Gudnason, Vilmundur, Li, Xiaojuan
Format: Text
Language:unknown
Published: MaineHealth Knowledge Connection 2014
Subjects:
Absorptiometry
Photon
Adipose Tissue
Aged
80 and over
Biomarkers
Bone Density
Bone Marrow
Bone Morphogenetic Proteins
Cohort Studies
Cross-Sectional Studies
Female
Genetic Markers
Humans
Iceland
Male
Osteocytes
Osteoporosis
Sex Characteristics
Tomography
X-Ray Computed
Endocrinology
Diabetes
and Metabolism
Genetics
Geriatrics
Online Access:https://knowledgeconnection.mainehealth.org/mmc/119
https://www.ncbi.nlm.nih.gov/pubmed/25144629/
Description
Summary:CONTEXT: Osteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationship between osteocyte activity and MF. OBJECTIVE: Our objective was to assess the relationships between circulating sclerostin, vertebral MF, volumetric bone mineral density (vBMD), and other fat depots in older adults. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort. MAIN OUTCOME MEASURES: Outcome measures included vertebral MF (L1-L4) measured with magnetic resonance spectroscopy and vBMD (spine and hip) and abdominal fat measured with quantitative computed tomography. RESULTS: After excluding subjects with bone-active medication use (n = 50), inadequate serum (n = 2), or inadequate magnetic resonance spectroscopy (n = 1), analyses included 115 men and 134 women (mean age 79 y, mean body mass index 27.7 kg/m(2)). In men, but not women, vertebral MF was greater in those with higher serum sclerostin levels. MF was 52.2 % in the lowest tertile of serum sclerostin and 56.3% in the highest tertile in men (P for trend CONCLUSION: Circulating sclerostin levels are associated with higher vertebral marrow fat in men, suggesting a relationship between osteocyte function and marrow adipogenesis.

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