Self-Assembly of Nanocellulose Hydrogels Mimicking Bacterial Cellulose for Wound Dressing Applications

The self-assembly of nanocellulose in the form of cellulose nanofibers (CNFs) can be accomplished via hydrogen-bonding assistance into completely bio-based hydrogels. This study aimed to use the intrinsic properties of CNFs, such as their ability to form strong networks and high absorption capacity...

Full description

Bibliographic Details
Published in:Biomacromolecules
Main Authors: Berglund, Linn, Squinca, Paula, Baş, Yağmur, Zattarin, Elisa, Aili, Daniel, Rakar, Jonathan, Junker, Johan, Starkenberg, Annika, Diamanti, Mattia, Sivlér, Petter, Skog, Mårten, Oksman, Kristiina
Format: Article in Journal/Newspaper
Language:English
Published: Linköpings universitet, Biofysik och bioteknik 2023
Subjects:
Materials Engineering
Materialteknik
Kempe
Luleå
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-194111
https://doi.org/10.1021/acs.biomac.3c00152
Description
Summary:The self-assembly of nanocellulose in the form of cellulose nanofibers (CNFs) can be accomplished via hydrogen-bonding assistance into completely bio-based hydrogels. This study aimed to use the intrinsic properties of CNFs, such as their ability to form strong networks and high absorption capacity and exploit them in the sustainable development of effective wound dressing materials. First, TEMPO-oxidized CNFs were separated directly from wood (W-CNFs) and compared with CNFs separated from wood pulp (P-CNFs). Second, two approaches were evaluated for hydrogel self-assembly from W-CNFs, where water was removed from the suspensions via evaporation through suspension casting (SC) or vacuum-assisted filtration (VF). Third, the W-CNF-VF hydrogel was compared to commercial bacterial cellulose (BC). The study demonstrates that the self-assembly via VF of nanocellulose hydrogels from wood was the most promising material as wound dressing and displayed comparable properties to that of BC and strength to that of soft tissue. Funding agencies: This work was financially supported by the Swedish Foundation for Strategic Research within the HEALiX project [RMX18-0039]; Bio4Energy, a strategic research environment, appointed by the Swedish government; and the Luleå University of Technology’s initiative “Natural Resources for Sustainability transitions” (SUN). Kempe Foundations is acknowledged for the funding of AFM equipment. We gratefully thank Dr. Simon Jonasson for help with the CNF preparation.

Similar Items