Strong association between glucocerebrosidase mutations and Parkinsons disease in Sweden

• Published in: Neurobiology of Aging
• Main Authors: Ran, Caroline, Brodin, Lovisa, Forsgren, Lars, Westerlund, Marie, Ramezani, Mehrafarin, Gellhaar, Sandra, Xiang, Fengqing, Fardell, Camilla, Nissbrandt, Hans, Söderkvist, Peter, Puschmann, Andreas, Ygland, Emil, Olson, Lars, Willows, Thomas, Johansson, Anders, Sydow, Olof, Wirdefeldt, Karin, Galter, Dagmar, Svenningsson, Per, Carmine Belin, Andrea
• Format: Article in Journal/Newspaper
• Language: English
• Published: Linköpings universitet, Avdelningen för cellbiologi 2016
• Subjects: Genetics; Lysosome; alpha-Synuclein; Gauchers disease; GBA; Medical Genetics and Genomics; Medicinsk genetik och genomik; Alf; Northern Sweden
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-131500; https://doi.org/10.1016/j.neurobiolaging.2016.04.022

Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gauchers disease, and an increased risk of Parkinsons disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population...