| Summary: | Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn Skoða/Opna(view/open) Eight laboratories participated in quality assessment of cholesterol, HDL cholesterol and triglycerides. The assessment was in two parts, first freeze-dried animal serum from Nycomed at three different concentration levels (A, B and C) was distributed and analysed once a day for 10 consecutive days along with patients' sera and then six months later frozen human plasma at two different concentration levels (R and S) was distributed and analysed the same way as before. The same analytical methods were used by all participants, with reagents purchased from three different producers. Five different analytical instruments are in operation in the 8 laboratories. The analytical quality is expressed as within-laboratory, between-laboratory and total imprecision. The average total imprecision for cholesterol is 6.3%, with a negligible bias from the assigned value of the control material at lower concentration levels, but -4.3% bias at 10.4 mmol/1 when animal sera were analysed. HDL cholesterol measurements show an average total imprecision of 16.0% and a large negative bias when animal serum was used. Average total imprecision for triglyceride measurements at three different concentration levels was 12.2%, which is almost twice as high as that for cholesterol. This survey indicates that there is scope for reducing interlaboratory differences, by improving the calibration of both the cholesterol and the triglyceride methods and by improving the HDL separation technique. Við mat á áhættuþáttum kransæðasjúkdóma er vitneskja um magn kólesteróls í blóði talin nauðsynleg. Hátt kólesteról í blóði eykur verulega hættu á hjarta- og æðasjúkdómum og eykst áhættan með hækkandi gildum (1,2). Í nokkrum nágrannalöndum hafa verið sett tiltekin mörk (3,4,5) og reynist kólesterólmagnið ofan við þau, tekur læknir ákvörðun um inngrip og fylgist síðan með breytingum á kólesterólinu. Hérlendis hefur ekki verið ákveðið, hvort setja ...
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