Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two new...

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Bibliographic Details
Published in:Nature Genetics
Main Authors: Gudmundsson, Julius, Sulem, Patrick, Rafnar, Thorunn, Bergthorsson, Jon T, Manolescu, Andrei, Gudbjartsson, Daniel, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Blondal, Thorarinn, Jakobsdottir, Margret, Stacey, Simon N, Kostic, Jelena, Kristinsson, Kari T, Birgisdottir, Birgitta, Ghosh, Shyamali, Magnusdottir, Droplaug N, Thorlacius, Steinunn, Thorleifsson, Gudmar, Zheng, S Lilly, Sun, Jielin, Chang, Bao-Li, Elmore, J Bradford, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Yaspan, Brian L, Wiklund, Fredrik, Stattin, Par, Lindström, Sara, Adami, Hans-Olov, McDonnell, Shannon K, Schaid, Daniel J, Cunningham, Julie M, Wang, Liang, Cerhan, James R, St Sauver, Jennifer L, Isaacs, Sara D, Wiley, Kathleen E, Partin, Alan W, Walsh, Patrick C, Polo, Sonia, Ruiz-Echarri, Manuel, Navarrete, Sebastian, Fuertes, Fernando, Saez, Berta, Godino, Javier, Weijerman, Philip C, Swinkels, Dorine W, Aben, Katja K
Other Authors: deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is
Format: Article in Journal/Newspaper
Language:English
Published: Nature Pub. Co. 2009
Subjects:
Case-Control Studies
Chromosomes
Human
Pair 2
X
Gene Frequency
Genetic Predisposition to Disease
Genetic Screening
Humans
Iceland
Linkage Disequilibrium
Male
Netherlands
Polymorphism
Single Nucleotide
Prostatic Neoplasms
Spain
Sweden
United States
Smella
Online Access:http://hdl.handle.net/2336/87460
https://doi.org/10.1038/ng.89
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Summary:Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

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