Variant in the sequence of the LINGO1 gene confers risk of essential tremor

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences o...

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Bibliographic Details
Published in:Nature Genetics
Main Authors: Stefansson, Hreinn, Steinberg, Stacy, Petursson, Hjorvar, Gustafsson, Omar, Gudjonsdottir, Iris H, Jonsdottir, Gudrun A, Palsson, Stefan T, Jonsson, Thorlakur, Saemundsdottir, Jona, Bjornsdottir, Gyda, Böttcher, Yvonne, Thorlacius, Theodora, Haubenberger, Dietrich, Zimprich, Alexander, Auff, Eduard, Hotzy, Christoph, Testa, Claudia M, Miyatake, Lisa A, Rosen, Ami R, Kristleifsson, Kristleifur, Rye, David, Asmus, Friedrich, Schöls, Ludger, Dichgans, Martin, Jakobsson, Finnbogi, Benedikz, John, Thorsteinsdottir, Unnur, Gulcher, Jeffrey, Kong, Augustine, Stefansson, Kari
Other Authors: deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: 2009
Subjects:
Animals
Austria
Essential Tremor
Gene Frequency
Genetic Predisposition to Disease
Genetics
Population
Genome-Wide Association Study
Germany
Humans
Iceland
Linkage Disequilibrium
Membrane Proteins
Mice
Knockout
Nerve Tissue Proteins
Polymorphism
Single Nucleotide
Risk Factors
United States
Online Access:http://hdl.handle.net/2336/84794
https://doi.org/10.1038/ng.299
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]

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