Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs1093485...
Published in: | Nature Genetics |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Pub. Co.
2009
|
Subjects: | |
Online Access: | http://hdl.handle.net/2336/84474 https://doi.org/10.1038/ng.448 |
id |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/84474 |
---|---|
record_format |
openpolar |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/84474 2023-05-15T16:50:41+02:00 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Blondal, Thorarinn Gylfason, Arnaldur Agnarsson, Bjarni A Benediktsdottir, Kristrun R Magnusdottir, Droplaug N Orlygsdottir, Gudbjorg Jakobsdottir, Margret Stacey, Simon N Sigurdsson, Asgeir Wahlfors, Tiina Tammela, Teuvo Breyer, Joan P McReynolds, Kate M Bradley, Kevin M Saez, Berta Godino, Javier Navarrete, Sebastian Fuertes, Fernando Murillo, Laura Polo, Eduardo Aben, Katja K van Oort, Inge M Suarez, Brian K Helfand, Brian T Kan, Donghui Zanon, Carlo Frigge, Michael L Kristjansson, Kristleifur Gulcher, Jeffrey R Einarsson, Gudmundur V Jonsson, Eirikur Catalona, William J Mayordomo, Jose I Kiemeney, Lambertus A Smith, Jeffrey R Schleutker, Johanna Barkardottir, Rosa B Kong, Augustine Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari deCODE Genetics, Reykjavik, Iceland. 2009-10-20 http://hdl.handle.net/2336/84474 https://doi.org/10.1038/ng.448 en eng Nature Pub. Co. info:eu-repo/grantAgreement/EC/FP7/218071 http://dx.doi.org/10.1038/ng.448 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/ Nat. Genet. 2009, 41(10):1122-6 1546-1718 19767754 doi:10.1038/ng.448 http://hdl.handle.net/2336/84474 Nature genetics openAccess DNA DNA Replication Disease Susceptibility European Continental Ancestry Group Genome Human Genome-Wide Association Study Humans Iceland Male Polymorphism Single Nucleotide Prostatic Neoplasms Risk Factors Article 2009 ftlandspitaliuni https://doi.org/10.1038/ng.448 2022-05-29T08:21:26Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. info:eu-repo/grantAgreement/EC/FP7/218071 European Union 202059 V Foundation US Department of Veterans Affairs Academy of Finland Sigrid Juselius Foundation Pirkanmaa Hospital District, Tampere University Hospital Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Sigrid ENVELOPE(-64.233,-64.233,-64.250,-64.250) Nature Genetics 41 10 1122 1126 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
DNA DNA Replication Disease Susceptibility European Continental Ancestry Group Genome Human Genome-Wide Association Study Humans Iceland Male Polymorphism Single Nucleotide Prostatic Neoplasms Risk Factors |
spellingShingle |
DNA DNA Replication Disease Susceptibility European Continental Ancestry Group Genome Human Genome-Wide Association Study Humans Iceland Male Polymorphism Single Nucleotide Prostatic Neoplasms Risk Factors Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Blondal, Thorarinn Gylfason, Arnaldur Agnarsson, Bjarni A Benediktsdottir, Kristrun R Magnusdottir, Droplaug N Orlygsdottir, Gudbjorg Jakobsdottir, Margret Stacey, Simon N Sigurdsson, Asgeir Wahlfors, Tiina Tammela, Teuvo Breyer, Joan P McReynolds, Kate M Bradley, Kevin M Saez, Berta Godino, Javier Navarrete, Sebastian Fuertes, Fernando Murillo, Laura Polo, Eduardo Aben, Katja K van Oort, Inge M Suarez, Brian K Helfand, Brian T Kan, Donghui Zanon, Carlo Frigge, Michael L Kristjansson, Kristleifur Gulcher, Jeffrey R Einarsson, Gudmundur V Jonsson, Eirikur Catalona, William J Mayordomo, Jose I Kiemeney, Lambertus A Smith, Jeffrey R Schleutker, Johanna Barkardottir, Rosa B Kong, Augustine Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
topic_facet |
DNA DNA Replication Disease Susceptibility European Continental Ancestry Group Genome Human Genome-Wide Association Study Humans Iceland Male Polymorphism Single Nucleotide Prostatic Neoplasms Risk Factors |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. info:eu-repo/grantAgreement/EC/FP7/218071 European Union 202059 V Foundation US Department of Veterans Affairs Academy of Finland Sigrid Juselius Foundation Pirkanmaa Hospital District, Tampere University Hospital |
author2 |
deCODE Genetics, Reykjavik, Iceland. |
format |
Article in Journal/Newspaper |
author |
Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Blondal, Thorarinn Gylfason, Arnaldur Agnarsson, Bjarni A Benediktsdottir, Kristrun R Magnusdottir, Droplaug N Orlygsdottir, Gudbjorg Jakobsdottir, Margret Stacey, Simon N Sigurdsson, Asgeir Wahlfors, Tiina Tammela, Teuvo Breyer, Joan P McReynolds, Kate M Bradley, Kevin M Saez, Berta Godino, Javier Navarrete, Sebastian Fuertes, Fernando Murillo, Laura Polo, Eduardo Aben, Katja K van Oort, Inge M Suarez, Brian K Helfand, Brian T Kan, Donghui Zanon, Carlo Frigge, Michael L Kristjansson, Kristleifur Gulcher, Jeffrey R Einarsson, Gudmundur V Jonsson, Eirikur Catalona, William J Mayordomo, Jose I Kiemeney, Lambertus A Smith, Jeffrey R Schleutker, Johanna Barkardottir, Rosa B Kong, Augustine Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari |
author_facet |
Gudmundsson, Julius Sulem, Patrick Gudbjartsson, Daniel F Blondal, Thorarinn Gylfason, Arnaldur Agnarsson, Bjarni A Benediktsdottir, Kristrun R Magnusdottir, Droplaug N Orlygsdottir, Gudbjorg Jakobsdottir, Margret Stacey, Simon N Sigurdsson, Asgeir Wahlfors, Tiina Tammela, Teuvo Breyer, Joan P McReynolds, Kate M Bradley, Kevin M Saez, Berta Godino, Javier Navarrete, Sebastian Fuertes, Fernando Murillo, Laura Polo, Eduardo Aben, Katja K van Oort, Inge M Suarez, Brian K Helfand, Brian T Kan, Donghui Zanon, Carlo Frigge, Michael L Kristjansson, Kristleifur Gulcher, Jeffrey R Einarsson, Gudmundur V Jonsson, Eirikur Catalona, William J Mayordomo, Jose I Kiemeney, Lambertus A Smith, Jeffrey R Schleutker, Johanna Barkardottir, Rosa B Kong, Augustine Thorsteinsdottir, Unnur Rafnar, Thorunn Stefansson, Kari |
author_sort |
Gudmundsson, Julius |
title |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
title_short |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
title_full |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
title_fullStr |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
title_full_unstemmed |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
title_sort |
genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
publisher |
Nature Pub. Co. |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/84474 https://doi.org/10.1038/ng.448 |
long_lat |
ENVELOPE(-64.233,-64.233,-64.250,-64.250) |
geographic |
Sigrid |
geographic_facet |
Sigrid |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/218071 http://dx.doi.org/10.1038/ng.448 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/ Nat. Genet. 2009, 41(10):1122-6 1546-1718 19767754 doi:10.1038/ng.448 http://hdl.handle.net/2336/84474 Nature genetics |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1038/ng.448 |
container_title |
Nature Genetics |
container_volume |
41 |
container_issue |
10 |
container_start_page |
1122 |
op_container_end_page |
1126 |
_version_ |
1766040803971432448 |