Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs1093485...

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Bibliographic Details
Published in:Nature Genetics
Main Authors: Gudmundsson, Julius, Sulem, Patrick, Gudbjartsson, Daniel F, Blondal, Thorarinn, Gylfason, Arnaldur, Agnarsson, Bjarni A, Benediktsdottir, Kristrun R, Magnusdottir, Droplaug N, Orlygsdottir, Gudbjorg, Jakobsdottir, Margret, Stacey, Simon N, Sigurdsson, Asgeir, Wahlfors, Tiina, Tammela, Teuvo, Breyer, Joan P, McReynolds, Kate M, Bradley, Kevin M, Saez, Berta, Godino, Javier, Navarrete, Sebastian, Fuertes, Fernando, Murillo, Laura, Polo, Eduardo, Aben, Katja K, van Oort, Inge M, Suarez, Brian K, Helfand, Brian T, Kan, Donghui, Zanon, Carlo, Frigge, Michael L, Kristjansson, Kristleifur, Gulcher, Jeffrey R, Einarsson, Gudmundur V, Jonsson, Eirikur, Catalona, William J, Mayordomo, Jose I, Kiemeney, Lambertus A, Smith, Jeffrey R, Schleutker, Johanna, Barkardottir, Rosa B, Kong, Augustine, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Stefansson, Kari
Other Authors: deCODE Genetics, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Nature Pub. Co. 2009
Subjects:
DNA
DNA Replication
Disease Susceptibility
European Continental Ancestry Group
Genome
Human
Genome-Wide Association Study
Humans
Iceland
Male
Polymorphism
Single Nucleotide
Prostatic Neoplasms
Risk Factors
Sigrid
Online Access:http://hdl.handle.net/2336/84474
https://doi.org/10.1038/ng.448
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. info:eu-repo/grantAgreement/EC/FP7/218071 European Union 202059 V Foundation US Department of Veterans Affairs Academy of Finland Sigrid Juselius Foundation Pirkanmaa Hospital District, Tampere University Hospital

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