| Summary: | Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Little information is available on upper uroepithelial tumors in Iceland. These tumors are rare, but important, presenting with similar symptoms as renal cell carcinomas (hematuria/pain) or urinary bladder carcinomas (hematuria). The aim of this study was to evalute incidence, presentation, diagnosis and survival of patients with uroepithelial tumors. A retrospective population-based study was carried out on all patients diagnosed in Iceland between 1971 and 1990 with carcinoma of the renal pelvis (n=45) and ureter (n=13). There were 42 men and 16 women with the mean age of 70 years. Transitional cell carcinomas were diagnosed in all except two cases (leiomyosarcomas). Most of the patients (86%) underwent radical nephroureterectomy with a two percent operative mortality. Presenting symptoms and diagnosis were evaluated and patients were staged (Grabstald staging system). Probability of survival was calculated for every stage and multivariate analysis used to find independent prognostic factors. Age adjusted incidence for carcinoma of the renal pelvis was 1,1/105 males and 0,4/105 females per year. Comparable figures for ureteral carcinoma were 0,4/103 males and 0,1/10^ females, respectively. Most of the patients presented with hematuria and abdominal or flank pain. Of 54 staged patients 28 were stage I-III (54%) and 24 stage IV (46%). Metastasis were found in 22% of the patients, most often in lymph nodes and lungs. Crude five year survival was 44% for the group as a whole, 88% for stage I and 21% for stage IV. Year of diagnosis was not an independent prognostic factor. Carcinomas of the ureter and renal pelvis are uncommon. Incidence in Iceland is relatively low and the clinical presentation similar to neighboring countries. Survival is comparable, in particular for patients with metastasis, but it has not changed for the last two decades. Harla lítið er vitað um krabbamein í nýrnaskjóðu og þvagleiðurum ...
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