Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. DESIGN: Cross-sectional, random, population-based...

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Bibliographic Details
Published in:Ophthalmology
Main Authors: Zoega, Gunnar M, Fujisawa, Aya, Sasaki, Hiroshi, Kubota, Akiko, Sasaki, Kazuyuki, Kitagawa, Kazuko, Jonasson, Fridbert
Format: Article in Journal/Newspaper
Language:English
Published: 2006
Subjects:
Age Distribution
Aged
80 and over
Cell Count
Corneal Diseases
Cross-Sectional Studies
Descemet Membrane
Endothelium
Corneal
Female
Humans
Iceland/epidemiology
Male
Middle Aged
Prevalence
Research Support
Non-U.S. Gov't
Risk Factors
Sex Distribution
Iceland
Online Access:http://hdl.handle.net/2336/6486
https://doi.org/10.1016/j.ophtha.2005.12.014
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. DESIGN: Cross-sectional, random, population-based study. PARTICIPANTS: The 774 participants were those participating in the second examination of the Reykjavik Eye Study. At baseline, we had a response rate of 75.8%, and at the 5-year follow-up, 88% of the survivors participated. METHODS: We used slit-lamp and non-contact specular microscopy and endothelial specular photography as well as computer-assisted morphometry. We used a standardized grading system for CG. MAIN OUTCOME MEASURES: Diagnosis of primary central CG. RESULTS: The prevalence of CG is 11% for females and 7% for males both for right eyes and left eyes. Higher weight and higher body mass index are found to be associated with decreased risk of CG. Having smoked more than 20 pack-years increased the risk of CG more than 2-fold (P<0.02). CONCLUSIONS: Cornea guttata seem to be found more commonly in women than in men. Smoking for more than 20 pack-years increases the risk of developing CG more than 2-fold.

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