Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies.

• Published in: Blood Cancer Journal
• Main Authors: Rögnvaldsson, Sæmundur, Love, Thorvardur Jon, Thorsteinsdottir, Sigrun, Reed, Elín Ruth, Óskarsson, Jón Þórir, Pétursdóttir, Íris, Sigurðardóttir, Guðrún Ásta, Viðarsson, Brynjar, Önundarson, Páll Torfi, Agnarsson, Bjarni A, Sigurðardóttir, Margrét, Þorsteinsdóttir, Ingunn, Ólafsson, Ísleifur, Þórðardóttir, Ásdís Rósa, Eyþórsson, Elías, Jónsson, Ásbjörn, Björnsson, Andri S, Gunnarsson, Gunnar Þór, Pálsson, Runólfur, Indriðason, Ólafur Skúli, Gíslason, Gauti Kjartan, Ólafsson, Andri, Hákonardóttir, Guðlaug Katrín, Brinkhuis, Manje, Halldórsdóttir, Sara Lovísa, Ásgeirsdóttir, Tinna Laufey, Steingrímsdóttir, Hlíf, Danielsen, Ragnar, Dröfn Wessman, Inga, Kampanis, Petros, Hulcrantz, Malin, Durie, Brian G M, Harding, Stephen, Landgren, Ola, Kristinsson, Sigurður Yngvi
• Other Authors: 1Faculty of Medicine, Univeristy of Iceland, Reykjavík, Iceland. 2Dept of Hematology, Rigshospitalet, Copenhagen, Denmark. 3Landspítali University Hospital, Reykjavík, Iceland. 4Faculty of Psychology, University of Iceland, Reykjavik, Iceland. 5Akureyri Hospital, Akureyri, Iceland. 6Faculty of Economics, University of Iceland, Reykjavik, Iceland. 7The Binding Site, Birmingham, West Midlands, UK. 8Memorial Sloan Kettering Cancer Center, New York, NY, USA. 9Cedar-Sinai Samual Oschin Cancer Center, Los Angeles, CA, USA. 10Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. 11Faculty of Medicine, Univeristy of Iceland, Reykjavík, Iceland. [e-mail]. 12Landspítali University Hospital, Reykjavík, Iceland. [e-mail].
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2021
• Subjects: Mergæxli; Skimun; Multiple Myeloma; Iceland; Mass Screening
• Online Access: http://hdl.handle.net/2336/621875; https://doi.org/10.1038/s41408-021-00480-w

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma study (iStopMM), the first population-based screening study for MGUS including a randomized trial of follow-up strategies. Icelandic residents born before 1976 were offered participation. Blood samples are collected alongside blood sampling in the Icelandic healthcare system. Participants with MGUS are randomized to three study arms. Arm 1 is not contacted, arm 2 follows current guidelines, and arm 3 follows a more intensive strategy. Participants who progress are offered early treatment. Samples are collected longitudinally from arms 2 and 3 for the study biobank. All participants repeatedly answer questionnaires on various exposures and outcomes including quality of life and psychiatric health. National registries on health are cross-linked to all participants. Of the 148,704 individuals in the target population, 80 759 (54.3%) provided informed consent for participation. With a very high participation rate, the data from the iStopMM study will answer important questions on MGUS, including potentials harms and benefits of screening. The study can lead to a paradigm shift in MM therapy towards screening and early therapy. Black Swan Research Initiative by the International Myeloma Foundation Icelandic Centre for Research European Research Council (ERC) University of Iceland Landspitali University Hospital