Mode of delivery was associated with transient changes in the metabolomic profile of neonates.

• Published in: Acta Paediatrica
• Main Authors: Vidarsdottir, Harpa, Halldorsson, Thorhallur Ingi, Geirsson, Reynir Tomas, Bjarnason, Ragnar, Franzson, Leifur, Valdimarsdottir, Unnur Anna, Thorkelsson, Thordur
• Other Authors: 1Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 2Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. 3Faculty for Food Science and Nutrition, School of Health Science, University of Iceland, Reykjavik, Iceland. 4Women's Clinic, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 5Children's Hospital Iceland, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 6Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland. 7Department of Genetics and Molecular Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 8Center for Public Health Science, School of Health Science, University of Iceland, Reykjavik, Iceland. 9Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 10Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2021
• Subjects: acylcarnitines; amino acids; delivery mode; metabolomic profile; newborn screening; Fæðing; Ungbörn; Efnaskipti; Delivery; Obstetric; Neonatal Screening; Metabolism; Iceland
• Online Access: http://hdl.handle.net/2336/621765; https://doi.org/10.1111/apa.15822

To access publisher's full text version of this article click on the hyperlink below Aims: To estimate potential differences in neonatal metabolomic profiles at birth and at the time of newborn screening by delivery mode. Methods: A prospective study at Women's Clinic at Landspitali-The National University Hospital of Iceland. Women having normal vaginal birth or elective caesarean section from November 2013 to April 2014 were offered participation. Blood samples from mothers before birth and umbilical cord at birth were collected and amino acids and acylcarnitines measured by tandem mass spectrometry. Results from the Newborn screening programme in Iceland were collected. Amino acids and acylcarnitines from different samples were compared by delivery mode. Results: Eighty three normal vaginal births and 32 elective caesarean sections were included. Mean differences at birth were higher for numerous amino acids, and some acylcarnitines in neonates born vaginally compared to elective caesarean section. Maternal blood samples and newborn screening results showed small differences that lost significance after correction for multiple testing. Many amino acids and some acylcarnitines were numerically higher in cord blood compared to maternal. Many amino acids and most acylcarnitines were numerically higher in newborn screening results compared to cord blood. Conclusion: We observed transient yet distinct differences in metabolomic profiles between neonates by delivery mode. Keywords: acylcarnitines; amino acids; delivery mode; metabolomic profile; newborn screening. University of Iceland Research Fund