A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
To access publisher's full text version of this article click on the hyperlink below Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (us...
Published in: | Nature Genetics |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Nature Publishing Group
2019
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Online Access: | http://hdl.handle.net/2336/620874 https://doi.org/10.1038/s41588-018-0314-6 |
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Hirsla - Landspítali University Hospital research archive |
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Nefkok Slímhúð Nefsjúkdómar Gen Nasal Polyps Sinusitis Genome-Wide Association Study |
spellingShingle |
Nefkok Slímhúð Nefsjúkdómar Gen Nasal Polyps Sinusitis Genome-Wide Association Study Kristjansson, Ragnar P Benonisdottir, Stefania Davidsson, Olafur B Oddsson, Asmundur Tragante, Vinicius Sigurdsson, Jon K Stefansdottir, Lilja Jonsson, Stefan Jensson, Brynjar O Arthur, Joseph G Arnadottir, Gudny A Sulem, Gerald Halldorsson, Bjarni V Gunnarsson, Bjarni Halldorsson, Gisli H Stefansson, Olafur A Oskarsson, Gudjon R Deaton, Aimee M Olafsson, Isleifur Eyjolfsson, Gudmundur I Sigurdardottir, Olof Onundarson, Pall T Gislason, David Gislason, Thorarinn Ludviksson, Bjorn R Ludviksdottir, Dora Olafsdottir, Thorunn A Rafnar, Thorunn Masson, Gisli Zink, Florian Bjornsdottir, Gyda Magnusson, Olafur Th Bjornsdottir, Unnur S Thorleifsson, Gudmar Norddahl, Gudmundur L Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Jonsdottir, Ingileif Sulem, Patrick Stefansson, Kari A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
topic_facet |
Nefkok Slímhúð Nefsjúkdómar Gen Nasal Polyps Sinusitis Genome-Wide Association Study |
description |
To access publisher's full text version of this article click on the hyperlink below Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10 National Institute of Dental and Craniofacial Research of the National Institutes of Health |
author2 |
1 deCODE genetics/Amgen Inc., Reykjavik, Iceland. 2 Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands. 3 School of Science and Engineering, Reykjavik University, Reykjavik, Iceland. 4 Department of Clinical Biochemistry, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 5 The Laboratory in Mjodd, RAM, Reykjavik, Iceland. 6 Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland. 7 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 8 Department of Laboratory Hematology, Landspítali, the National University Hospital of Iceland, Reykjavik, Iceland. 9 Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 10 Department of Sleep, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 11 Department of Immunology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 12 Department of Respiratory Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 13 The Medical Center Mjodd, Reykjavik, Iceland. 14 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 15 deCODE genetics/Amgen Inc., Reykjavik, Iceland. patrick.sulem@decode.is. 16 deCODE genetics/Amgen Inc., Reykjavik, Iceland. kari.stefansson@decode.is. 17 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. kari.stefansson@decode.is. |
format |
Article in Journal/Newspaper |
author |
Kristjansson, Ragnar P Benonisdottir, Stefania Davidsson, Olafur B Oddsson, Asmundur Tragante, Vinicius Sigurdsson, Jon K Stefansdottir, Lilja Jonsson, Stefan Jensson, Brynjar O Arthur, Joseph G Arnadottir, Gudny A Sulem, Gerald Halldorsson, Bjarni V Gunnarsson, Bjarni Halldorsson, Gisli H Stefansson, Olafur A Oskarsson, Gudjon R Deaton, Aimee M Olafsson, Isleifur Eyjolfsson, Gudmundur I Sigurdardottir, Olof Onundarson, Pall T Gislason, David Gislason, Thorarinn Ludviksson, Bjorn R Ludviksdottir, Dora Olafsdottir, Thorunn A Rafnar, Thorunn Masson, Gisli Zink, Florian Bjornsdottir, Gyda Magnusson, Olafur Th Bjornsdottir, Unnur S Thorleifsson, Gudmar Norddahl, Gudmundur L Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Jonsdottir, Ingileif Sulem, Patrick Stefansson, Kari |
author_facet |
Kristjansson, Ragnar P Benonisdottir, Stefania Davidsson, Olafur B Oddsson, Asmundur Tragante, Vinicius Sigurdsson, Jon K Stefansdottir, Lilja Jonsson, Stefan Jensson, Brynjar O Arthur, Joseph G Arnadottir, Gudny A Sulem, Gerald Halldorsson, Bjarni V Gunnarsson, Bjarni Halldorsson, Gisli H Stefansson, Olafur A Oskarsson, Gudjon R Deaton, Aimee M Olafsson, Isleifur Eyjolfsson, Gudmundur I Sigurdardottir, Olof Onundarson, Pall T Gislason, David Gislason, Thorarinn Ludviksson, Bjorn R Ludviksdottir, Dora Olafsdottir, Thorunn A Rafnar, Thorunn Masson, Gisli Zink, Florian Bjornsdottir, Gyda Magnusson, Olafur Th Bjornsdottir, Unnur S Thorleifsson, Gudmar Norddahl, Gudmundur L Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Jonsdottir, Ingileif Sulem, Patrick Stefansson, Kari |
author_sort |
Kristjansson, Ragnar P |
title |
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
title_short |
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
title_full |
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
title_fullStr |
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
title_full_unstemmed |
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. |
title_sort |
loss-of-function variant in alox15 protects against nasal polyps and chronic rhinosinusitis. |
publisher |
Nature Publishing Group |
publishDate |
2019 |
url |
http://hdl.handle.net/2336/620874 https://doi.org/10.1038/s41588-018-0314-6 |
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Iceland |
genre_facet |
Iceland |
op_source |
Nature genetics |
op_relation |
https://www.nature.com/articles/s41588-018-0314-6 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 2019, 51(2):267-276 Nat Genet 1546-1718 30643255 doi:10.1038/s41588-018-0314-6 http://hdl.handle.net/2336/620874 Nature genetics |
op_rights |
Landspitali Access - LSH-aðgangur |
op_doi |
https://doi.org/10.1038/s41588-018-0314-6 |
container_title |
Nature Genetics |
container_volume |
51 |
container_issue |
2 |
container_start_page |
267 |
op_container_end_page |
276 |
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1766040043936284672 |
spelling |
ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/620874 2023-05-15T16:49:52+02:00 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. Kristjansson, Ragnar P Benonisdottir, Stefania Davidsson, Olafur B Oddsson, Asmundur Tragante, Vinicius Sigurdsson, Jon K Stefansdottir, Lilja Jonsson, Stefan Jensson, Brynjar O Arthur, Joseph G Arnadottir, Gudny A Sulem, Gerald Halldorsson, Bjarni V Gunnarsson, Bjarni Halldorsson, Gisli H Stefansson, Olafur A Oskarsson, Gudjon R Deaton, Aimee M Olafsson, Isleifur Eyjolfsson, Gudmundur I Sigurdardottir, Olof Onundarson, Pall T Gislason, David Gislason, Thorarinn Ludviksson, Bjorn R Ludviksdottir, Dora Olafsdottir, Thorunn A Rafnar, Thorunn Masson, Gisli Zink, Florian Bjornsdottir, Gyda Magnusson, Olafur Th Bjornsdottir, Unnur S Thorleifsson, Gudmar Norddahl, Gudmundur L Gudbjartsson, Daniel F Thorsteinsdottir, Unnur Jonsdottir, Ingileif Sulem, Patrick Stefansson, Kari 1 deCODE genetics/Amgen Inc., Reykjavik, Iceland. 2 Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands. 3 School of Science and Engineering, Reykjavik University, Reykjavik, Iceland. 4 Department of Clinical Biochemistry, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 5 The Laboratory in Mjodd, RAM, Reykjavik, Iceland. 6 Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland. 7 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 8 Department of Laboratory Hematology, Landspítali, the National University Hospital of Iceland, Reykjavik, Iceland. 9 Department of Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 10 Department of Sleep, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 11 Department of Immunology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 12 Department of Respiratory Medicine, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland. 13 The Medical Center Mjodd, Reykjavik, Iceland. 14 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 15 deCODE genetics/Amgen Inc., Reykjavik, Iceland. patrick.sulem@decode.is. 16 deCODE genetics/Amgen Inc., Reykjavik, Iceland. kari.stefansson@decode.is. 17 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. kari.stefansson@decode.is. 2019-04 http://hdl.handle.net/2336/620874 https://doi.org/10.1038/s41588-018-0314-6 en eng Nature Publishing Group https://www.nature.com/articles/s41588-018-0314-6 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 2019, 51(2):267-276 Nat Genet 1546-1718 30643255 doi:10.1038/s41588-018-0314-6 http://hdl.handle.net/2336/620874 Nature genetics Landspitali Access - LSH-aðgangur Nature genetics Nefkok Slímhúð Nefsjúkdómar Gen Nasal Polyps Sinusitis Genome-Wide Association Study Article 2019 ftlandspitaliuni https://doi.org/10.1038/s41588-018-0314-6 2022-05-29T08:22:25Z To access publisher's full text version of this article click on the hyperlink below Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10 National Institute of Dental and Craniofacial Research of the National Institutes of Health Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Nature Genetics 51 2 267 276 |