A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
To access publisher's full text version of this article click on the hyperlink below Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (us...
Published in: | Nature Genetics |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2019
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Subjects: | |
Online Access: | http://hdl.handle.net/2336/620874 https://doi.org/10.1038/s41588-018-0314-6 |
Summary: | To access publisher's full text version of this article click on the hyperlink below Nasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10 National Institute of Dental and Craniofacial Research of the National Institutes of Health |
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