Antibacterial Susceptibilities of Escherichia coli from Community-Acquired Urinary Tract Infections in the Faroe Islands, Associations with Antibacterial Sales, and Comparison with Iceland and Denmark

• Published in: Microbial Drug Resistance
• Main Authors: Magnussen, Marita Debess, Gislason, Hannes, Gaini, Shahin, Kristinsson, Karl G.
• Other Authors: 1 Thetis, Food & Environm Lab, Vio Myllutjorn 6, FO-100 Torshavn, Faroe Islands, Denmark Show more 2 Univ Iceland, Med Fac, Reykjavik, Iceland 3 Univ Faroe Isl, Fac Sci & Technol, Torshavn, Faroe Islands, Denmark 4 Queen Alexandrines Teaching Hosp, Natl Hosp Faroe Isl, Dept Internal Med, Torshavn, Faroe Islands, Denmark 5 Queen Alexandrines Teaching Hosp, Natl Hosp Faroe Isl, Med Dept, Res Unit, Torshavn, Faroe Islands, Denmark Show more 6 Odense Univ Hosp, Dept Infect Dis, Odense, Denmark Show more 7 Univ Southern Denmark, Odense, Denmark Show more 8 Landspitali Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland, Thetis, Food and Environmental Laboratory, Tórshavn, Faroe Islands., Faculty of Science and Technology, University of the Faroe Islands, Tórshavn, Faroe Islands., Medical Faculty, University of Iceland, Reykjavík, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Mary Ann Liebert 2018
• Subjects: Þvagfærasjúkdómar; Gerlar; Lyfhrifafræði; Sýklalyf; BAC12; Escherichia coli; Drug Resistance; Bacterial; Urinary Tract Infections; Eik; Faroe Islands; Iceland
• Online Access: http://hdl.handle.net/2336/620460; https://doi.org/10.1089/mdr.2017.0034

To access publisher's full text version of this article click on the hyperlink below Currently, data on Escherichia coli antibacterial susceptibilities in the Faroe Islands are lacking. The aim was to investigate the antibacterial susceptibilities of E. coli from patients with community-acquired urinary tract infections in the Faroe Islands, correlate with antibacterial sales, and compare with Iceland and Denmark. From 2009 to 2010 and in 2012, 12 general practitioners from the Faroe Islands were recruited to provide urine samples from patients. Antibacterial susceptibilities were determined by disc diffusion testing according to the Clinical and Laboratory Standards Institute methods and criteria. Logistic regression (quasibinomial) of the antibacterial resistance proportions versus mean sales during the period of 2008-2011 was used to determine association. Nonsusceptibility to at least 1 of the 14 antibacterial drugs investigated was found in 54% of the E. coli isolates and was most common to ampicillin (46%), followed by sulfamethoxazole (39%), trimethoprim (27%), trimethoprim/sulfamethoxazole (27%), and <10% to the remaining 10 antibiotics. The resistance prevalence did not change significantly with time. From logistic regression modeling, we find significant associations between antibacterial mean sales and antibacterial resistances. For the resistances in the Faroe Islands compared with data from Denmark and Iceland, we infer two groups of resistances indicating different responses-one steep and one gradual-to antibacterial sales. For these two groups, we find β1 = 4.77 (Std. Error = 0.624, p-value = 0.002) and β1 = 0.26 (Std. Error = 0.020, p-value = 4e-7) for the steep and gradual groups, respectively. This knowledge can potentially be used to predict and control the future increase in E. coli resistance with antibacterial sales. Faroese research Council BP Amoco Chevron Texaco Eik Visindagrunninum SSAC foundation