Long-Term Hormone Replacement Therapy Is Associated with Low Coronary Artery Calcium Levels in a Cohort of Older Women: The Age, Gene/Environment Susceptibility-Reykjavik Study.

• Published in: Journal of the American Geriatrics Society
• Main Authors: Gudmundsson, Adalsteinn, Aspelund, Thor, Sigurdsson, Gunnar, Harris, Tamara, Launer, Lenore J, Gudnason, Vilmundur, Jonsson, Helgi
• Other Authors: 1 Landspitali University Hospital, Reykjavik, Iceland. 2 University of Iceland, Reykjavik, Iceland. 3 Icelandic Heart Association, Kopavogur, Iceland. 4 Intramural Research Program, National Institute on Aging, Bethesda, Maryland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley-Blackwell 2017
• Subjects: Hormónameðferð; Kransæðasjúkdómar; END12; RHE12; GER12; Coronary Artery Disease; Hormone Replacement Therapy; Iceland
• Online Access: http://hdl.handle.net/2336/620241; https://doi.org/10.1111/jgs.14461

To access publisher's full text version of this article click on the hyperlink below To assess the relationship between hormone replacement therapy (HRT) and coronary artery calcium (CAC). Cross-sectional. Established population-based cohort in Reykjavik, Iceland. Women (mean age 76 ± 5) who had completed questionnaires on HRT use (N = 2,867). Coronary artery calcium assessed using computed tomography was the outcome variable and was compared between women with history of HRT and those who had never used HRT and analyzed according to age, length of use, and time after menopause that HRT was initiated. Eight hundred seventy-two (30.4%) participants had used HRT, and 312 (10.9%) were current users. After adjustment for age, other late-life variables, and a propensity score based on midlife data for HRT use as observed in late life, there were significant negative associations between CAC and history and length of HRT use. This association was evident in all age categories. When HRT had been used for longer than 15 years, median CAC level was less than 50% of that observed in never users. The lowest CAC was observed in those who started HRT within 5 years after menopause. The prevalence of coronary events was comparable in both groups. A strong association was found between long-term HRT use and low CAC. The negative association between duration of HRT and CAC was evident in all age groups of older women. National Institutes of Health (NIH) National Institute on Aging Intramural Research Program, Hjartavernd (The Icelandic Heart Association) Althing (The Icelandic Parliament)