Adult height associates with angiographic extent of coronary artery disease.

• Published in: Atherosclerosis
• Main Authors: Bjornsson, Eythor, Thorgeirsson, Gudmundur, Gudnason, Thorarinn
• Other Authors: 1Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland. 2Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland. 3Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2016
• Subjects: Æðakölkun; Kransæðasjúkdómar; Líkamshæð; CAR12; Atherosclerosis; Coronary Angiography; Coronary Artery Disease; Body Height; Iceland
• Online Access: http://hdl.handle.net/2336/619854; https://doi.org/10.1016/j.atherosclerosis.2016.07.918

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Shorter stature is an established risk factor for coronary artery disease (CAD), but less is known about its association with extent of the disease. We assessed the relationship between self-reported height and angiographic findings in 7706 men and 3572 women identified from a nationwide coronary angiography registry in Iceland. After adjustment for traditional cardiovascular risk factors, a standard deviation decrease in height associated with a greater likelihood of significant CAD (defined as ≥50% luminal diameter stenosis) both in men (adjusted odds ratio [ORadj]: 1.24, 95% confidence interval [CI]: 1.18, 1.31; p = 3.2 × 10(-16)) and women (ORadj = 1.10, 95% CI: 1.02, 1.18; p = 0.012). In partial proportional odds logistic regression models, a standard deviation decrease in height was associated with higher odds of having greater extent of CAD in men (ORadj = 1.19, 95% CI: 1.15, 1.25; p = 1.5 × 10(-16)) and women (ORadj = 1.09, 95% CI: 1.02, 1.16; p = 0.014). When limited to patients with significant CAD, the association was statistically significant in men (ORadj = 1.08, 95% CI: 1.03, 1.14; p = 0.0022) but not in women (p = 0.56). Our findings show that shorter stature is associated with greater extent of coronary atherosclerosis in a large unselected population of individuals undergoing coronary angiography. This relationship appears to be sex-dependent, with stronger effects in men than in women. Landspitali University Hospital Research Fund, Jonína Gísladottir fund, Bent Scheving Thorsteinsson research fund, and Research Fund of the Icelandic Society of Cardiology.