Increasing Prevalence of Addison Disease: Results From a Nationwide Study

• Published in: Endocrine Practice
• Main Authors: Olafsson, Andri Snaer, Sigurjonsdottir, Helga Agusta
• Other Authors: 1 Univ Iceland, Fac Med, Reykjavik, Iceland 2 Landspitali Natl Univ Hosp, Dept Endocrinol, IS-108 Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital
• Format: Article in Journal/Newspaper
• Language: English
• Published: Amer Assoc Clinical Endocrinologists 2016
• Subjects: Hjarta- og æðasjúkdómar; Aldraðir; Hormónameðferð; END12; Addison Disease; Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Female; Hormone Replacement Therapy; Humans; Hydrocortisone; Iceland; Male; Middle Aged; Prevalence; Hjarta
• Online Access: http://hdl.handle.net/2336/618523; https://doi.org/10.4158/EP15754.OR

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Primary adrenal insufficiency is a life-threatening endocrine disease unless properly treated. However, few studies on the prevalence, concomitances of the disease, and prescribing of drugs have been published. The goal of the study was to establish the prevalence of primary adrenal insufficiency in Iceland and additionally, to study the most common concomitant diseases in patients with primary adrenal insufficiency, as well as the mode of glucocorticoid replacement therapies. To achieve this, the medical records of all patients in Iceland who had received the International Classification of Diseases and Related Health Problems, 10th Revision, diagnosis code E27, were evaluated for true primary adrenal insufficiency. Additionally, these records were evaluated for concomitant diseases, as well as the mode of glucocorticoid replacement therapy. The study covered the whole population of Iceland over 18 years of age. It was thus a nationwide study. The records were retrieved from large hospitals and clinics and every practicing specialist in endocrinology. Primary adrenal insufficiency was found in 53 individuals, 26 women and 27 men, yielding a prevalence of 22.1 per 100,000 population. Hypothyroidism was by far the most common concomitant disease. Most patients had their glucocorticoid deficiency replaced with short-acting glucocorticoids. The prevalence of primary adrenal insufficiency in Iceland is higher than in earlier reports, with comorbidities being in line with recent studies. Treatment is according to the latest protocols.