A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Achillea millefolium has been used in traditional medicine for a number of ailments, including skin inflammation and wounds. A polysaccharide fraction (Am-25-d) isolated from aqueous extract...

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Published in:Carbohydrate Polymers
Main Authors: Freysdottir, Jona, Logadottir, Oddny T, Omarsdottir, Sesselja S, Vikingsson, Arnor, Hardardottir, Ingibjorg
Other Authors: 1 Landspitali, Ctr Rheumatol Res, IS-101 Reykjavik, Iceland 2 Univ Iceland, Biomed Ctr, Fac Med, Dept Immunol, IS-101 Reykjavik, Iceland 3 Landspitali, Dept Immunol, IS-101 Reykjavik, Iceland 4 Univ Iceland, Biomed Ctr, Fac Med, Dept Biochem & Mol Biol, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland 5 Univ Iceland, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2016
Subjects:
NAF12
RHE12
Achillea
Cytokines
MAP Kinase Kinase Kinases
Polysaccharides
Iceland
Online Access:http://hdl.handle.net/2336/613367
https://doi.org/10.1016/j.carbpol.2016.02.017
id ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/613367
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spelling ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/613367 2023-05-15T16:50:57+02:00 A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes. Freysdottir, Jona Logadottir, Oddny T Omarsdottir, Sesselja S Vikingsson, Arnor Hardardottir, Ingibjorg 1 Landspitali, Ctr Rheumatol Res, IS-101 Reykjavik, Iceland 2 Univ Iceland, Biomed Ctr, Fac Med, Dept Immunol, IS-101 Reykjavik, Iceland 3 Landspitali, Dept Immunol, IS-101 Reykjavik, Iceland 4 Univ Iceland, Biomed Ctr, Fac Med, Dept Biochem & Mol Biol, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland 5 Univ Iceland, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland 2016 http://hdl.handle.net/2336/613367 https://doi.org/10.1016/j.carbpol.2016.02.017 en eng Elsevier http://dx.doi.org/ 10.1016/j.carbpol.2016.02.017 A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes. 2016, 143:131-8 Carbohydr Polym 1879-1344 27083352 doi:10.1016/j.carbpol.2016.02.017 http://hdl.handle.net/2336/613367 Carbohydrate polymers Archived with thanks to Carbohydrate polymers National Consortium - Landsaðgangur NAF12 RHE12 Achillea Cytokines MAP Kinase Kinase Kinases Polysaccharides Article 2016 ftlandspitaliuni https://doi.org/10.1016/j.carbpol.2016.02.017 2022-05-29T08:22:10Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page Achillea millefolium has been used in traditional medicine for a number of ailments, including skin inflammation and wounds. A polysaccharide fraction (Am-25-d) isolated from aqueous extract from A. millefolium had an average molecular weight of 270kDa and a monosaccharide composition of GalA, Gal, Ara, Xyl, Rha in molar ratio of 28:26:23:9:7. THP-1 cells primed with IFN-γ and stimulated with LPS in the presence of Am-25-d secreted more IL-1β, IL-8, IL-10, IL-12p40, IL-23 and TNF-α than THP-1 cells stimulated in the absence of Am-25-d. However, when added to unstimulated cells Am-25-d did not increase secretion of the cytokines examined. Stimulating THP-1 monocytes in the presence of Am-25-d led to decreased nuclear concentrations of NF-κB and phosphorylation of ERK1/2 and Akt kinases compared with that when the cells were stimulated without Am-25-d. These findings indicate that Am-25-d isolated from A. millefolium has immunoenhancing properties that may be mediated via the Akt pathway. Icelandic Research Fund/110418021 University of Iceland Research Fund Landspitali University Hospital Research Fund Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Carbohydrate Polymers 143 131 138
institution Open Polar
collection Hirsla - Landspítali University Hospital research archive
op_collection_id ftlandspitaliuni
language English
topic NAF12
RHE12
Achillea
Cytokines
MAP Kinase Kinase Kinases
Polysaccharides
spellingShingle NAF12
RHE12
Achillea
Cytokines
MAP Kinase Kinase Kinases
Polysaccharides
Freysdottir, Jona
Logadottir, Oddny T
Omarsdottir, Sesselja S
Vikingsson, Arnor
Hardardottir, Ingibjorg
A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
topic_facet NAF12
RHE12
Achillea
Cytokines
MAP Kinase Kinase Kinases
Polysaccharides
description To access publisher's full text version of this article click on the hyperlink at the bottom of the page Achillea millefolium has been used in traditional medicine for a number of ailments, including skin inflammation and wounds. A polysaccharide fraction (Am-25-d) isolated from aqueous extract from A. millefolium had an average molecular weight of 270kDa and a monosaccharide composition of GalA, Gal, Ara, Xyl, Rha in molar ratio of 28:26:23:9:7. THP-1 cells primed with IFN-γ and stimulated with LPS in the presence of Am-25-d secreted more IL-1β, IL-8, IL-10, IL-12p40, IL-23 and TNF-α than THP-1 cells stimulated in the absence of Am-25-d. However, when added to unstimulated cells Am-25-d did not increase secretion of the cytokines examined. Stimulating THP-1 monocytes in the presence of Am-25-d led to decreased nuclear concentrations of NF-κB and phosphorylation of ERK1/2 and Akt kinases compared with that when the cells were stimulated without Am-25-d. These findings indicate that Am-25-d isolated from A. millefolium has immunoenhancing properties that may be mediated via the Akt pathway. Icelandic Research Fund/110418021 University of Iceland Research Fund Landspitali University Hospital Research Fund
author2 1 Landspitali, Ctr Rheumatol Res, IS-101 Reykjavik, Iceland 2 Univ Iceland, Biomed Ctr, Fac Med, Dept Immunol, IS-101 Reykjavik, Iceland 3 Landspitali, Dept Immunol, IS-101 Reykjavik, Iceland 4 Univ Iceland, Biomed Ctr, Fac Med, Dept Biochem & Mol Biol, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland 5 Univ Iceland, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland
format Article in Journal/Newspaper
author Freysdottir, Jona
Logadottir, Oddny T
Omarsdottir, Sesselja S
Vikingsson, Arnor
Hardardottir, Ingibjorg
author_facet Freysdottir, Jona
Logadottir, Oddny T
Omarsdottir, Sesselja S
Vikingsson, Arnor
Hardardottir, Ingibjorg
author_sort Freysdottir, Jona
title A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
title_short A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
title_full A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
title_fullStr A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
title_full_unstemmed A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes.
title_sort polysaccharide fraction from achillea millefolium increases cytokine secretion and reduces activation of akt, erk and nf-κb in thp-1 monocytes.
publisher Elsevier
publishDate 2016
url http://hdl.handle.net/2336/613367
https://doi.org/10.1016/j.carbpol.2016.02.017
genre Iceland
genre_facet Iceland
op_relation http://dx.doi.org/ 10.1016/j.carbpol.2016.02.017
A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes. 2016, 143:131-8 Carbohydr Polym
1879-1344
27083352
doi:10.1016/j.carbpol.2016.02.017
http://hdl.handle.net/2336/613367
Carbohydrate polymers
op_rights Archived with thanks to Carbohydrate polymers
National Consortium - Landsaðgangur
op_doi https://doi.org/10.1016/j.carbpol.2016.02.017
container_title Carbohydrate Polymers
container_volume 143
container_start_page 131
op_container_end_page 138
_version_ 1766041072019963904

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