Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study.

• Published in: Allergy
• Main Authors: Xepapadaki, P, Fiocchi, A, Grabenhenrich, L, Roberts, G, Grimshaw, K E C, Fiandor, A, Larco, J I, Sigurdardottir, S, Clausen, M, Papadopoulos, N G, Dahdah, L, Mackie, A, Sprikkelman, A B, Schoemaker, A A, Dubakiene, R, Butiene, I, Kowalski, M L, Zeman, K, Gavrili, S, Keil, T, Beyer, K
• Other Authors: 1 Univ Athens, Pediat Clin 2, Allergy Unit, Athens 11527, Greece 2 Pediat Hosp Bambino Gesu, Div Allergy, Rome, Italy 3 Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany 4 Univ Southampton, Clin Sci Acad Unit, Fac Med, Southampton, Hants, England 5 Univ Southampton, Expt Sci Acad Unit, Fac Med, Southampton, Hants, England 6 Hosp La Paz, Inst Hlth Res, Dept Allergy, Madrid, Spain 7 Landspitali, Dept Immunol, Reykjavik, Iceland 8 Landspitali, Childrens Hosp, Reykjavik, Iceland 9 Univ Manchester, Inst Human Dev, Ctr Paediat & Child Hlth, Manchester, Lancs, England 10 Inst Food Res, Norwich Res Pk, Norwich NR4 7UA, Norfolk, England 11 Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Resp Med & Allergy, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands 12 Vilnius Univ, Fac Med, Vilnius, Lithuania 13 Klaipeda Univ, Fac Hlth Sci, Klaipeda, Lithuania 14 Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland 15 Res Inst Lodz, Polish Mothers Hlth Ctr, Dept Pediat Immunol & Nephrol, Lodz, Poland 16 Alexandra Univ Hosp, Neonatal Intens Care Unit, Athens, Greece 17 Univ Wurzburg, Inst Clin Epidemiol & Biometry, D-97070 Wurzburg, Germany 18 Charite, Dept Paediat Pneumonol & Immunol, D-13353 Berlin, Germany
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley-Blackwell 2016
• Subjects: Ofnæmi; Börn; Egg; AAI12; Infant; Egg Hypersensitivity/epidemiology; Europe; Iceland
• Online Access: http://hdl.handle.net/2336/607253; https://doi.org/10.1111/all.12801

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis. European Commission FOOD-CT-2005-514000 Landspitali-The National University Hospital of Iceland Science Fund GlaxoSmithKline Iceland EuroPrevall: the United Kingdom birth cohort by the UK Food Standards Agency Grida MSD Nutricia Advanced Medical Nutrition ...