Insulin-like growth factor-1 and resistance exercise in community dwelling old adults

• Published in: The journal of nutrition, health & aging
• Main Authors: Arnarson, A, Gudny Geirsdottir, O, Ramel, A, Jonsson, P V, Thorsdottir, I
• Other Authors: 1 Natl Univ Hosp Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital 2 Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland 3 Natl Univ Hosp Iceland, Iceland Gerontol Res Ctr, IS-101 Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital 4 Fac Med, Reykjavik, Iceland 5 Natl Univ Hosp Iceland, Dept Geriatr, IS-101 Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital
• Format: Article in Journal/Newspaper
• Language: English
• Published: Springer France 2015
• Subjects: Aldraðir; Líkamasþyngd; Líkamsrækt; Energy Metabolism; Insulin-Like Growth Factor I; Ideal Body Weight; Aging; Resistance Training; Intervention Studies; Rho; Iceland
• Online Access: http://hdl.handle.net/2336/581813; https://doi.org/10.1007/s12603-015-0547-3

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Insulin-like growth factor-1 (IGF-1) is related to the preservation of lean body mass. Its decline during ageing is thought to make old adults more susceptible to sarcopenia and functional dependency. The aim of the present study was to investigate circulating total IGF-1 in old adults who engaged in a 12-weeks of progressive resistance training. Intervention study. Community. Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female). Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups. IGF-1. At baseline IGF-1 was significantly associated with lean body mass and appendicular muscle mass (also when corrected for age, gender and various covariates). After the training IGF-1 decreased significantly from 112.1 ± 35.6 to 106.1 ± 35.2 µg/L during the course of the study. On and individual level, IGF-1 decreased in 59% and increased in 39% of the participants. Changes in IGF-1 were inversely related to changes in lean body mass (rho = -0.176, P = 0.013 ) and appendicular muscle mass (rho = -0.162, P = 0.019) also when corrected for protein intake, age, gender, and other covariates. Serum total IGF-1 decreases after 12 weeks of resistance exercise in community dwelling old adults. When looked at IGF-1 changes for participants individually it becomes clear that IGF-1 response to resistances exercise is highly variable. Changes in IGF-1 are negatively related to changes in lean body mass during training, which supports the hypothesis that IGF-1 is redistributed from circulation into tissue during periods of active muscle building. Icelandic Technology Development Fund 071323008 University of Iceland Landspitali University Hospital Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund