Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.

To access publisher's full text version of this article click on the hyperlink at the bottom of the page Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activi...

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Bibliographic Details
Published in:Chemical Communications
Main Authors: Sahariah, Priyanka, Sørensen, Kasper K, Hjálmarsdóttir, Martha Á, Sigurjónsson, Ólafur E, Jensen, Knud J, Másson, Már, Thygesen, Mikkel B
Other Authors: 1 Univ Iceland, Sch Hlth Sci, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland 2 Univ Copenhagen, Ctr Carbohydrate Recognit & Signalling, Dept Chem, Fac Sci, DK-1871 Copenhagen, Denmark 3 Univ Iceland, Fac Med, Dept Biomed Sci, IS-101 Reykjavik, Iceland 4 Landspitali Univ Hosp, REModeL Lab, Blood Bank, IS-105 Reykjavik, Iceland 5 Reykjavik Univ, Inst Biomed & Neural Engn, IS-105 Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Royal Soc Chemistry 2015
Subjects:
Antimicrobial Cationic Peptides/chemical synthesis
Antimicrobial Cationic Peptides/pharmacology*
Iceland
Online Access:http://hdl.handle.net/2336/575053
https://doi.org/10.1039/c5cc04010h
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Summary:To access publisher's full text version of this article click on the hyperlink at the bottom of the page Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan. Danish National Research Foundation DNRF79 Icelandic Research Fund 120443021 University of Iceland Research Fund

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