Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Previous studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the a...
Published in: | American Journal of Respiratory and Critical Care Medicine |
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American Thoracic Society
2009
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Online Access: | http://hdl.handle.net/2336/47294 https://doi.org/10.1164/rccm.2107121 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/47294 2023-05-15T16:49:39+02:00 Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome Gislason, Thorarinn Johannsson, Johann Heidar Haraldsson, Asgeir Olafsdottir, Berglind Ran Jonsdottir, Helga Kong, Augustine Frigge, Michael L Jonsdottir, Guthrun M Hakonarson, Hakon Gulcher, Jeffrey Stefansson, Kari Department of Pulmonary Medicine, Vífilsstadir, Gardabaer, Iceland. thorarig@rsp.is 2009-01-12 http://hdl.handle.net/2336/47294 https://doi.org/10.1164/rccm.2107121 en eng American Thoracic Society http://ajrccm.atsjournals.org/cgi/content/abstract/166/6/833 Am. J. Respir. Crit. Care Med. 2002, 166(6):833-8 1073-449X 1535-4970 12231493 doi:10.1164/rccm.2107121 http://hdl.handle.net/2336/47294 American journal of respiratory and critical care medicine Adolescent Adult Age Factors Aged Cluster Analysis Confidence Intervals Databases Factual Female Genealogy and Heraldry Genetic Predisposition to Disease Iceland Infant Newborn Life Style Male Middle Aged Odds Ratio Positive-Pressure Respiration Risk Sex Factors Sleep Apnea Obstructive Sudden Infant Death Syndrome Article 2009 ftlandspitaliuni https://doi.org/10.1164/rccm.2107121 2022-05-29T08:21:14Z To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Previous studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the availability of too few cases of SIDS to draw conclusions. To examine the familial nature of this association in Iceland, hospital-based lists of all patients who were diagnosed with OSAS (n = 2,350) and SIDS (n = 58) from 1979 to 1998 were used to separately determine the familial occurrence of OSAS and SIDS and to search for evidence of cosegregation of these conditions in Icelandic families, using a nationwide genealogy database. The risk ratio for a first-degree relative of a patient with OSAS was 2.0 (1.7-2.8, 95% confidence interval). The risk ratio of the more severely affected patients with OSAS was slightly higher (2.3). Likewise, the kinship coefficient (KC) for the OSAS patient group, which determines the relatedness of the patients, was significantly larger than the mean KC of 1,000 matched control groups. Estimation of the KC for the SIDS group showed a trend toward significance when compared with control groups, but after excluding one of the half-siblings in the SIDS group from the analysis, the difference did not show any trend toward significance. Although the results of the analysis of the relatedness between all patients with OSAS and infants who died of SIDS were not significant, a trend toward significance was evident when the data were separately analyzed for the more severely affected patients with OSAS. Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS. Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive American Journal of Respiratory and Critical Care Medicine 166 6 833 838 |
institution |
Open Polar |
collection |
Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Adolescent Adult Age Factors Aged Cluster Analysis Confidence Intervals Databases Factual Female Genealogy and Heraldry Genetic Predisposition to Disease Iceland Infant Newborn Life Style Male Middle Aged Odds Ratio Positive-Pressure Respiration Risk Sex Factors Sleep Apnea Obstructive Sudden Infant Death Syndrome |
spellingShingle |
Adolescent Adult Age Factors Aged Cluster Analysis Confidence Intervals Databases Factual Female Genealogy and Heraldry Genetic Predisposition to Disease Iceland Infant Newborn Life Style Male Middle Aged Odds Ratio Positive-Pressure Respiration Risk Sex Factors Sleep Apnea Obstructive Sudden Infant Death Syndrome Gislason, Thorarinn Johannsson, Johann Heidar Haraldsson, Asgeir Olafsdottir, Berglind Ran Jonsdottir, Helga Kong, Augustine Frigge, Michael L Jonsdottir, Guthrun M Hakonarson, Hakon Gulcher, Jeffrey Stefansson, Kari Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
topic_facet |
Adolescent Adult Age Factors Aged Cluster Analysis Confidence Intervals Databases Factual Female Genealogy and Heraldry Genetic Predisposition to Disease Iceland Infant Newborn Life Style Male Middle Aged Odds Ratio Positive-Pressure Respiration Risk Sex Factors Sleep Apnea Obstructive Sudden Infant Death Syndrome |
description |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Previous studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the availability of too few cases of SIDS to draw conclusions. To examine the familial nature of this association in Iceland, hospital-based lists of all patients who were diagnosed with OSAS (n = 2,350) and SIDS (n = 58) from 1979 to 1998 were used to separately determine the familial occurrence of OSAS and SIDS and to search for evidence of cosegregation of these conditions in Icelandic families, using a nationwide genealogy database. The risk ratio for a first-degree relative of a patient with OSAS was 2.0 (1.7-2.8, 95% confidence interval). The risk ratio of the more severely affected patients with OSAS was slightly higher (2.3). Likewise, the kinship coefficient (KC) for the OSAS patient group, which determines the relatedness of the patients, was significantly larger than the mean KC of 1,000 matched control groups. Estimation of the KC for the SIDS group showed a trend toward significance when compared with control groups, but after excluding one of the half-siblings in the SIDS group from the analysis, the difference did not show any trend toward significance. Although the results of the analysis of the relatedness between all patients with OSAS and infants who died of SIDS were not significant, a trend toward significance was evident when the data were separately analyzed for the more severely affected patients with OSAS. Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS. |
author2 |
Department of Pulmonary Medicine, Vífilsstadir, Gardabaer, Iceland. thorarig@rsp.is |
format |
Article in Journal/Newspaper |
author |
Gislason, Thorarinn Johannsson, Johann Heidar Haraldsson, Asgeir Olafsdottir, Berglind Ran Jonsdottir, Helga Kong, Augustine Frigge, Michael L Jonsdottir, Guthrun M Hakonarson, Hakon Gulcher, Jeffrey Stefansson, Kari |
author_facet |
Gislason, Thorarinn Johannsson, Johann Heidar Haraldsson, Asgeir Olafsdottir, Berglind Ran Jonsdottir, Helga Kong, Augustine Frigge, Michael L Jonsdottir, Guthrun M Hakonarson, Hakon Gulcher, Jeffrey Stefansson, Kari |
author_sort |
Gislason, Thorarinn |
title |
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
title_short |
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
title_full |
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
title_fullStr |
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
title_full_unstemmed |
Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
title_sort |
familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome |
publisher |
American Thoracic Society |
publishDate |
2009 |
url |
http://hdl.handle.net/2336/47294 https://doi.org/10.1164/rccm.2107121 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://ajrccm.atsjournals.org/cgi/content/abstract/166/6/833 Am. J. Respir. Crit. Care Med. 2002, 166(6):833-8 1073-449X 1535-4970 12231493 doi:10.1164/rccm.2107121 http://hdl.handle.net/2336/47294 American journal of respiratory and critical care medicine |
op_doi |
https://doi.org/10.1164/rccm.2107121 |
container_title |
American Journal of Respiratory and Critical Care Medicine |
container_volume |
166 |
container_issue |
6 |
container_start_page |
833 |
op_container_end_page |
838 |
_version_ |
1766039797836546048 |