Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND PURPOSE: Incidental foci of signal loss suggestive of cerebral microbleeds (CMBs) are frequent findings on gradient echo T2* weighted MRI (T2* MRI) of patients with haemorrha...

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Bibliographic Details
Published in:Journal of Neurology, Neurosurgery & Psychiatry
Main Authors: Sveinbjornsdottir, S, Sigurdsson, S, Aspelund, T, Kjartansson, O, Eiriksdottir, G, Valtysdottir, B, Lopez, O L, van Buchem, M A, Jonsson, P V, Gudnason, V, Launer, L J
Other Authors: Department of Neurology, Landspitali University Hospital, C12, Fossvogur, 108 Reykjavik, Iceland. sigurls@landspitali.is
Format: Article in Journal/Newspaper
Language:English
Published: 2008
Subjects:
Aged
Apolipoprotein E4
Basal Ganglia
Cerebral Hemorrhage
Female
Genotype
Humans
Iceland
Magnetic Resonance Imaging
Male
Middle Aged
Prevalence
Risk Factors
Sex Factors
Online Access:http://hdl.handle.net/2336/41761
https://doi.org/10.1136/jnnp.2007.121913
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field BACKGROUND AND PURPOSE: Incidental foci of signal loss suggestive of cerebral microbleeds (CMBs) are frequent findings on gradient echo T2* weighted MRI (T2* MRI) of patients with haemorrhagic or ischaemic stroke. There are few prevalence data on older populations. This paper reports on the prevalence and location of CMBs in a community based cohort of older men and women (born 1907-1935) who participated in the Age Gene/Environment Susceptibility (AGES)-Reykjavik Study, a population based cohort study that followed the Reykjavik Study METHODS: As part of the examination, all eligible and consenting cohort members underwent a full brain MRI, and blood was drawn for genotyping. Results are based on the first 1962 men (n = 820) and women (n = 1142), mean age 76 years, with complete MRI and demographic information available. RESULTS: Evidence of CMBs was found in 218 participants (11.1% (95% CI 9.8% to 12.6%)); men had significantly more CMBs than women (14.4% vs 8.8%; p = 0.0002, age adjusted). The prevalence of CMBs increased with age (p = 0.0001) in both men (p = 0.006) and women (p = 0.007). CMBs were located in the cerebral lobes (70%), the basal ganglia region (10.5%) and infratentorium (18.6%). Having a CMB was significantly associated with a homozygote Apo E epsilon4epsilon4 genotype (p = 0.01). CONCLUSION: Cerebral microbleeds are common in older persons. The association with homozygote Apo E epsilon4 genotype and finding a relative predominance in the parietal lobes might indicate an association with amyloid angiopathy.

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