Lymphoid tumours of the ocular adnexa: a morphologic and genotypic study of 15 cases

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To examine all lymphoproliferative lesions of the ocular adnexa diagnosed in Iceland during 1983-2000 and to determine whether polymerase chain reaction (PCR) methods to determine...

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Bibliographic Details
Published in:Acta Ophthalmologica Scandinavica
Main Authors: Sigurdardottir, Margret, Sigurdsson, Haraldur, Barkardottir, Rosa Bjork, Kristjansdottir, Sigrun, Agnarsson, Bjarni A
Other Authors: Department of Pathology, University Hospital, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Blackwell 2008
Subjects:
Adult
Aged
80 and over
DNA
Neoplasm
Female
Genotype
Granuloma
Plasma Cell
Orbital
Humans
Hyperplasia
Iceland
Immunoenzyme Techniques
Lymphoma
Male
Middle Aged
Orbital Neoplasms
Polymerase Chain Reaction
Online Access:http://hdl.handle.net/2336/35775
https://doi.org/10.1034/j.1600-0420.2003.00067.x
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: To examine all lymphoproliferative lesions of the ocular adnexa diagnosed in Iceland during 1983-2000 and to determine whether polymerase chain reaction (PCR) methods to determine clonality are helpful in characterizing these lesions. METHODS: All patients diagnosed with lymphoproliferative lesions in the ocular adnexa in the years 1983-2000 were included in the study. Polymerase chain reaction studies for clonality were performed on these lesions. RESULTS: Fifteen cases were identified. Seven were classified as inflammatory pseudotumour, one as lymphoid hyperplasia, four as atypical lymphoid hyperplasia and three as lymphoma. Of 12 cases examined by PCR, three were monoclonal for B-cells (one lymphoma, one inflammatory pseudotumour and one atypical lymphoid hyperplasia) while the remaining lesions (including two lymphomas) appeared polyclonal. CONCLUSION: The results of this study suggest that analysis of clonality by PCR methods may be of limited use in classifying lymphoproliferative lesions of the ocular adnexa as benign or malignant. These results underscore the importance of using several techniques when determining clonality.

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