Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients.

• Published in: Sleep
• Main Authors: Sutherland, Kate, Schwab, Richard J, Maislin, Greg, Lee, Richard W W, Benedikstdsottir, Bryndis, Pack, Allan I, Gislason, Thorarinn, Juliusson, Sigurdur, Cistulli, Peter A
• Other Authors: Royal N Shore Hosp, Dept Resp Med, Ctr Sleep Hlth & Res, St Leonards, NSW 2065, Australia, Univ Sydney, NHMRC Ctr Integrated Res & Understanding Sleep CI, Sydney, NSW 2006, Australia, Univ Penn, Sch Med, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA, Univ Penn, Dept Med, Div Sleep Med, Philadelphia, PA 19104 USA, Gosford Hosp, Dept Resp Med, Gosford, Australia, Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW 2300, Australia, Univ Iceland, Fac Med, Reykjavik, Iceland, Landspitali Univ Hosp Fossvogi, Dept Resp Med & Sleep, Reykjavik, Iceland, Natl Univ Hosp Iceland, Dept Otolaryngol, Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Amer Acad Sleep Medicine 2015
• Subjects: Kæfisvefn; Offita; Líkamasþyngd; Áhættuþættir; Body Mass Index; Body Size; Body Weight; Craniofacial Abnormalities; Cross-Sectional Studies; Face; Female; Humans; Iceland; Magnetic Resonance Imaging; Male; Mandible; Middle Aged; Neck; Obesity; Phenotype; Photography; Respiratory System; Risk Factors; Sleep Apnea; Obstructive; Tongue
• Online Access: http://hdl.handle.net/2336/338662; https://doi.org/10.5665/sleep.3670

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field. This article is open access. (1) To determine whether facial phenotype, measured by quantitative photography, relates to underlying craniofacial obstructive sleep apnea (OSA) risk factors, measured with magnetic resonance imaging (MRI); (2) To assess whether these associations are independent of body size and obesity. Cross-sectional cohort. Landspitali, The National University Hospital, Iceland. One hundred forty patients (87.1% male) from the Icelandic Sleep Apnea Cohort who had both calibrated frontal and profile craniofacial photographs and upper airway MRI. Mean ± standard deviation age 56.1 ± 10.4 y, body mass index 33.5 ± 5.05 kg/m(2), with on-average severe OSA (apnea-hypopnea index 45.4 ± 19.7 h(-1)). N/A. Relationships between surface facial dimensions (photos) and facial bony dimensions and upper airway soft-tissue volumes (MRI) was assessed using canonical correlation analysis. Photo and MRI craniofacial datasets related in four significant canonical correlations, primarily driven by measurements of (1) maxillary-mandibular relationship (r = 0.8, P < 0.0001), (2) lower face height (r = 0.76, P < 0.0001), (3) mandibular length (r = 0.67, P < 0.0001), and (4) tongue volume (r = 0.52, P = 0.01). Correlations 1, 2, and 3 were unchanged when controlled for weight and neck and waist circumference. However, tongue volume was no longer significant, suggesting facial dimensions relate to tongue volume as a result of obesity. Significant associations were found between craniofacial variable sets from facial photography and MRI. This study confirms that facial photographic phenotype reflects underlying aspects of craniofacial skeletal abnormalities associated with OSA. Therefore, facial photographic phenotyping may be a useful tool to assess intermediate phenotypes for OSA, particularly in large-scale studies. NIH/P01 HL094307 Sleep Apnea Genetics International Consortium ...