Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology. Participants are 4,057 older men and wo...
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Online Access: | http://hdl.handle.net/2336/325564 https://doi.org/10.1212/WNL.0000000000000517 |
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ftlandspitaliuni:oai:www.hirsla.lsh.is:2336/325564 2023-05-15T16:51:49+02:00 Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. Muller, Majon Sigurdsson, Sigurdur Kjartansson, Olafur Aspelund, Thor Lopez, Oscar L Jonnson, Palmi V Harris, Tamara B van Buchem, Mark Gudnason, Vilmundur Launer, Lenore J Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. 2From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. 2014 http://hdl.handle.net/2336/325564 https://doi.org/10.1212/WNL.0000000000000517 en eng Lippincott Williams & Wilkins http://dx.doi.org/10.1212/WNL.0000000000000517 Neurology 2014, 82 (24):2187-95 1526-632X 24898928 doi:10.1212/WNL.0000000000000517 http://hdl.handle.net/2336/325564 Neurology Archived with thanks to Neurology Closed - Lokað Háþrýstingur Segulómun Heilinn Aldraðir Taugakerfi Blóðþrýstingur Minni Sjúkdómsgreiningar Adult Aged 80 and over Aging Analysis of Variance Blood Pressure Brain Cognition Disease Susceptibility Female Humans Hypertension Iceland Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Retrospective Studies Article 2014 ftlandspitaliuni https://doi.org/10.1212/WNL.0000000000000517 2022-05-29T08:21:59Z To access publisher's full text version of this article click on the hyperlink at the bottom of the page We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology. Participants are 4,057 older men and women without dementia with midlife (mean age 50 ± 6 years) and late-life (mean age 76 ± 5 years) vascular screening, cognitive function, and brain structures on MRI ascertained as part of the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. The association of late-life BP to brain measures depended on midlife hypertension history. Higher late-life systolic and diastolic BP (DBP) was associated with an increased risk of white matter lesions and cerebral microbleeds, and this was most pronounced in participants without a history of midlife hypertension. In contrast, in participants with a history of midlife hypertension, lower late-life DBP was associated with smaller total brain and gray matter volumes. This finding was reflected back in cognitive performance; in participants with midlife hypertension, lower DBP was associated with lower memory scores. In this large population-based cohort, late-life BP differentially affects brain pathology and cognitive performance, depending on the history of midlife hypertension. Our study suggests history of hypertension is critical to understand how late-life BP affects brain structure and function. NIH/N01-AG-1-2100 National Institute on Aging Intramural Research Program Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) Alzheimer Nederland/WE.15-2011-02 Article in Journal/Newspaper Iceland Hirsla - Landspítali University Hospital research archive Neurology 82 24 2187 2195 |
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Hirsla - Landspítali University Hospital research archive |
op_collection_id |
ftlandspitaliuni |
language |
English |
topic |
Háþrýstingur Segulómun Heilinn Aldraðir Taugakerfi Blóðþrýstingur Minni Sjúkdómsgreiningar Adult Aged 80 and over Aging Analysis of Variance Blood Pressure Brain Cognition Disease Susceptibility Female Humans Hypertension Iceland Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Retrospective Studies |
spellingShingle |
Háþrýstingur Segulómun Heilinn Aldraðir Taugakerfi Blóðþrýstingur Minni Sjúkdómsgreiningar Adult Aged 80 and over Aging Analysis of Variance Blood Pressure Brain Cognition Disease Susceptibility Female Humans Hypertension Iceland Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Retrospective Studies Muller, Majon Sigurdsson, Sigurdur Kjartansson, Olafur Aspelund, Thor Lopez, Oscar L Jonnson, Palmi V Harris, Tamara B van Buchem, Mark Gudnason, Vilmundur Launer, Lenore J Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
topic_facet |
Háþrýstingur Segulómun Heilinn Aldraðir Taugakerfi Blóðþrýstingur Minni Sjúkdómsgreiningar Adult Aged 80 and over Aging Analysis of Variance Blood Pressure Brain Cognition Disease Susceptibility Female Humans Hypertension Iceland Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Retrospective Studies |
description |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology. Participants are 4,057 older men and women without dementia with midlife (mean age 50 ± 6 years) and late-life (mean age 76 ± 5 years) vascular screening, cognitive function, and brain structures on MRI ascertained as part of the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. The association of late-life BP to brain measures depended on midlife hypertension history. Higher late-life systolic and diastolic BP (DBP) was associated with an increased risk of white matter lesions and cerebral microbleeds, and this was most pronounced in participants without a history of midlife hypertension. In contrast, in participants with a history of midlife hypertension, lower late-life DBP was associated with smaller total brain and gray matter volumes. This finding was reflected back in cognitive performance; in participants with midlife hypertension, lower DBP was associated with lower memory scores. In this large population-based cohort, late-life BP differentially affects brain pathology and cognitive performance, depending on the history of midlife hypertension. Our study suggests history of hypertension is critical to understand how late-life BP affects brain structure and function. NIH/N01-AG-1-2100 National Institute on Aging Intramural Research Program Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) Alzheimer Nederland/WE.15-2011-02 |
author2 |
Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. 2From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. |
format |
Article in Journal/Newspaper |
author |
Muller, Majon Sigurdsson, Sigurdur Kjartansson, Olafur Aspelund, Thor Lopez, Oscar L Jonnson, Palmi V Harris, Tamara B van Buchem, Mark Gudnason, Vilmundur Launer, Lenore J |
author_facet |
Muller, Majon Sigurdsson, Sigurdur Kjartansson, Olafur Aspelund, Thor Lopez, Oscar L Jonnson, Palmi V Harris, Tamara B van Buchem, Mark Gudnason, Vilmundur Launer, Lenore J |
author_sort |
Muller, Majon |
title |
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
title_short |
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
title_full |
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
title_fullStr |
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
title_full_unstemmed |
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study. |
title_sort |
joint effect of mid- and late-life blood pressure on the brain: the ages-reykjavik study. |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2014 |
url |
http://hdl.handle.net/2336/325564 https://doi.org/10.1212/WNL.0000000000000517 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://dx.doi.org/10.1212/WNL.0000000000000517 Neurology 2014, 82 (24):2187-95 1526-632X 24898928 doi:10.1212/WNL.0000000000000517 http://hdl.handle.net/2336/325564 Neurology |
op_rights |
Archived with thanks to Neurology Closed - Lokað |
op_doi |
https://doi.org/10.1212/WNL.0000000000000517 |
container_title |
Neurology |
container_volume |
82 |
container_issue |
24 |
container_start_page |
2187 |
op_container_end_page |
2195 |
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1766041926901956608 |