Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
To access publisher's full text version of this article click on the hyperlink at the bottom of the page We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology. Participants are 4,057 older men and wo...
Published in: | Neurology |
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Main Authors: | , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Lippincott Williams & Wilkins
2014
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Subjects: | |
Online Access: | http://hdl.handle.net/2336/325564 https://doi.org/10.1212/WNL.0000000000000517 |
Summary: | To access publisher's full text version of this article click on the hyperlink at the bottom of the page We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology. Participants are 4,057 older men and women without dementia with midlife (mean age 50 ± 6 years) and late-life (mean age 76 ± 5 years) vascular screening, cognitive function, and brain structures on MRI ascertained as part of the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. The association of late-life BP to brain measures depended on midlife hypertension history. Higher late-life systolic and diastolic BP (DBP) was associated with an increased risk of white matter lesions and cerebral microbleeds, and this was most pronounced in participants without a history of midlife hypertension. In contrast, in participants with a history of midlife hypertension, lower late-life DBP was associated with smaller total brain and gray matter volumes. This finding was reflected back in cognitive performance; in participants with midlife hypertension, lower DBP was associated with lower memory scores. In this large population-based cohort, late-life BP differentially affects brain pathology and cognitive performance, depending on the history of midlife hypertension. Our study suggests history of hypertension is critical to understand how late-life BP affects brain structure and function. NIH/N01-AG-1-2100 National Institute on Aging Intramural Research Program Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) Alzheimer Nederland/WE.15-2011-02 |
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