Risk factors for nuclear lens opacification: the Reykjavik Eye Study.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: The purpose of this study is to examine risk factors for nuclear lens opacification in citizens of Reykjavik. METHODS: 1,045 persons, 583 females and 462 males aged 50 years and ol...

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Bibliographic Details
Main Authors: Arnarsson, Arsaell, Jonasson, Fridbert, Sasaki, Hiroshi, Ono, Masaji, Jonsson, Vesteinn, Kojima, Masami, Katoh, Nobuyo, Sasaki, Kazuyuki
Other Authors: Department of Ophthalmology, University Hospital, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Karger 2008
Subjects:
Aged
80 and over
Aging
Cataract
Female
Humans
Iceland
Lens Nucleus
Crystalline
Male
Middle Aged
Photography
Questionnaires
Risk Factors
Smoking
Online Access:http://hdl.handle.net/2336/31603
https://doi.org/10.1159/000060804
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field PURPOSE: The purpose of this study is to examine risk factors for nuclear lens opacification in citizens of Reykjavik. METHODS: 1,045 persons, 583 females and 462 males aged 50 years and older, were randomly sampled and underwent a detailed eye examination and answered a questionnaire. In all Scheimpflug photography of the anterior eye segment was done including the lens as well as retroilluminated photography of the lens. These photographs were used for the diagnosis of lens opacification. The data was analyzed using a logistic regression model. RESULTS: An increased risk for all grades of nuclear opacifications was found with ageing (OR = 1.228, 95% CI = 1.192-1.264, p = 0.000), cigarette smoking for more than 20 pack/years (OR = 2.521, 95% CI = 1.521-4.125, p = 0.000) and pipe or cigar smoking (OR = 2.478, 95% CI = 1.200-5.116, p = 0.014). Outdoor exposure, cortical lens opacification grade II and III and computer usage were not found to be linked to higher risk of nuclear opacification. No correlation was found between nuclear opacification and the consumption of vitamins, herring, sardines and shrimps, cod-liver oil or plant oil, nor were iris color, hyperopia, systemic steroid use, cardiovascular disease, diabetes, glaucoma and pseudoexfoliation found to have a significant effect. CONCLUSIONS: Ageing is a major risk factor for nuclear lens opacification, and smoking is a major modifiable risk factor. Cortical and nuclear lens opacifications do not share the same modifiable risk factors.

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