Endothelial-rich microenvironment supports growth and branching morphogenesis of prostate epithelial cells.

• Published in: The Prostate
• Main Authors: Bergthorsson, Jon Thor, Magnusson, Magnus Karl, Gudjonsson, Thorarinn
• Other Authors: Univ Iceland, Sch Hlth Sci, Biomed Ctr, Stem Cell Res Unit, Reykjavik, Iceland, Univ Iceland, Sch Hlth Sci, Dept Pharmacol & Toxicol, Reykjavik, Iceland, Landspitali Univ Hosp, Dept Lab Hematol, Reykjavik, Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley-Blackwell 2013
• Subjects: Frumurannsóknir; Blöðruhálskirtill; Cell Line; Epithelial Cells; Epithelial-Mesenchymal Transition; Flow Cytometry; Humans; Immunohistochemistry; Male; Morphogenesis; Organ Culture Techniques; Prostate; Iceland
• Online Access: http://hdl.handle.net/2336/312637; https://doi.org/10.1002/pros.22634

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Development of epithelial organs depends on interaction between the epithelium and the underlying mesenchyme including the vasculature. The aim of this study was to explore the morphogenic effect of endothelial cells on prostate epithelial cell lines in 3D culture and to establish an in vitro model for prostate branching morphogenesis. Icelandic Centre for Research/100444042 Icelandic Cancer Society University of Iceland Research Fund Bergthora Magnusdottir and Jakob J. Bjarnasson Memory Fund