An unusually low prevalence of Huntington's disease in Iceland.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary movements and psychiatric disturbances, found worldwide, with a varia...

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Bibliographic Details
Published in:European Neurology
Main Authors: Sveinsson, Olafur, Halldórsson, Sigurður, Olafsson, Elias
Other Authors: Department of Neurology, Landspitali University Hospital, Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Karger 2013
Subjects:
Adult
Female
History
16th Century
Humans
Huntington Disease
Iceland
Incidence
Male
Middle Aged
Prevalence
Young Adult
Huntington
Norway
Online Access:http://hdl.handle.net/2336/301913
https://doi.org/10.1159/000337680
Description
Summary:To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary movements and psychiatric disturbances, found worldwide, with a variable prevalence. The purpose of this study was to determine the history of HD in Iceland and determine the prevalence and incidence of HD. Clinical information was obtained from general, neurologic, and psychiatric hospitals, practicing neurologists, general practitioners, and family members of affected individuals. Twenty-seven individuals were identified with typical symptoms of HD from the 1850s to 2007. All but one sporadic case are descendants of a husband and wife living in the early and mid-19th century. The point prevalence of HD in Iceland is 1.0 per 100,000 individuals. The prevalence of HD in Iceland is markedly lower than in the neighboring countries (Norway and the British Isles), where Icelanders originate from Iceland's University research fund

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