Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey.

Nocturnal gastroesophageal reflux (nGER) has received increasing interest as a predisposing factor for respiratory diseases and sleep disturbances. The possible role of obstructive sleep apnea (OSA) contributing to nGER is of special interest. The aim of this study was to explore the association bet...

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Bibliographic Details
Published in:Respiratory Medicine
Main Authors: Emilsson, Ossur Ingi, Janson, Christer, Benediktsdóttir, Bryndís, Júlíusson, Sigurdur, Gíslason, Thórarinn
Other Authors: Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
Format: Article in Journal/Newspaper
Language:English
Published: 2013
Subjects:
Adult
Age Factors
Aged
Body Mass Index
Cross-Sectional Studies
Female
Forced Expiratory Volume
Gastroesophageal Reflux
Humans
Iceland
Lung
Male
Middle Aged
Respiration Disorders
Sex Factors
Sleep Apnea
Obstructive
Spirometry
Sweden
Vital Capacity
Online Access:http://hdl.handle.net/2336/298079
https://doi.org/10.1016/j.rmed.2011.12.004
Description
Summary:Nocturnal gastroesophageal reflux (nGER) has received increasing interest as a predisposing factor for respiratory diseases and sleep disturbances. The possible role of obstructive sleep apnea (OSA) contributing to nGER is of special interest. The aim of this study was to explore the association between nGER and respiratory diseases, lung function and symptoms of OSA. Participants in the Burden of Obstructive Lung Disease (BOLD) initiative in Iceland and Sweden, a random sample from the general population of 1325 adults aged 40+ (>70% response rate), were compared by pre- and post-bronchodilator spirometry, answers to questionnaires about OSA and respiratory symptoms, health, and symptoms of GER. Altogether 102 (7.7%) reported nGER and 249 had used medication against GER. The participants were divided into three groups: 1) No nGER (n = 1040), 2) treated GER without nGER (n = 183) and 3) nGER (n = 102). The nGER group had a significantly higher prevalence of respiratory and OSA symptoms than subjects without nGER. The nGER group also had a higher prevalence of COPD (GOLD stage 1+), (25.0% vs. 15.6%) (p = 0.02) and lower FEV(1)/FVC ratio (95.9% vs. 98.9% of the predicted, p = 0.01). These associations remained significant after adjusting for smoking, weight and other possible confounders. No independent association was found between having treated GER and lung function, respiratory or OSA symptoms. In our cross-sectional epidemiological study, untreated nGER is strongly associated with both respiratory and OSA symptoms as well as airflow obstruction. Landspitali-University Astra Zeneca in Iceland GlaxoSmithKline in Iceland Swedish Heart and Lung Foundation Swedish Heart and Lung Association GlaxoSmithKline, Sweden

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