Clinical significance of Staphylococcus aureus bacteriuria in a nationwide study of adults with S. aureus bacteraemia.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVES: To evaluate the clinical significance of Staphylococcus aureus bacteriuria (SABU) in adults with S. aureus bacteraemia (SAB). METHODS: All individuals ≥18 years old diagnosed w...

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Bibliographic Details
Published in:Journal of Infection
Main Authors: Asgeirsson, Hilmir, Kristjansson, Mar, Kristinsson, Karl G, Gudlaugsson, Olafur
Other Authors: Department of Infectious Diseases, Landspitali University Hospital
Format: Article in Journal/Newspaper
Language:English
Published: 2012
Subjects:
Adult
Aged
Bacteremia
Bacteriuria
Female
Humans
Iceland
Male
Middle Aged
Retrospective Studies
Staphylococcal Infections
Staphylococcus aureus
Urine
Online Access:http://hdl.handle.net/2336/238390
https://doi.org/10.1016/j.jinf.2011.10.009
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. OBJECTIVES: To evaluate the clinical significance of Staphylococcus aureus bacteriuria (SABU) in adults with S. aureus bacteraemia (SAB). METHODS: All individuals ≥18 years old diagnosed with SAB in Iceland between December 1st 2003 and November 30th 2008 were retrospectively identified. Data was collected from medical records. Concomitant SABU was defined as growth of S. aureus in a urine sample taken within 24 h of the index blood culture. RESULTS: SABU was seen in 27 of 166 (16.3%) SAB patients having urine cultured before administration of antibiotics, but after excluding those with SAB of urinary tract origin SABU was seen in 16 of 152 (10.5%). In this latter cohort SABU was independently associated with having endocarditis (RR 6.68; 95% CI 1.53-17.3) and admission to intensive-care unit (RR 2.84; 95% CI 1.25-4.44), while for having complicated SAB the RR was 1.56 (95% CI 0.96-1.80). No correlation was seen with mortality or relapse rates. CONCLUSIONS: SABU appears to be secondary to SAB in some cases while it is the primary infection causing SAB in others. In patients with SAB of non-urinary tract origin SABU should probably be regarded as distant haematogenous seeding and a marker of deep tissue dissemination, thus affecting general management and treatment duration. Scientific Trust of Landspitali University Hospital

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