Support for involvement of the AHI1 locus in schizophrenia

• Published in: European Journal of Human Genetics
• Main Authors: Ingason, Andres, Sigmundsson, Thordur, Steinberg, Stacy, Sigurdsson, Engilbert, Haraldsson, Magnus, Magnusdottir, Brynja B, Frigge, Michael L, Kong, Augustine, Gulcher, Jeffrey, Thorsteinsdottir, Unnur, Stefansson, Kari, Petursson, Hannes, Stefansson, Hreinn
• Other Authors: deCODE genetics, Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2007
• Subjects: Adaptor Proteins; Signal Transducing; Case-Control Studies; Genetic Markers; Humans; Iceland; Schizophrenia
• Online Access: http://hdl.handle.net/2336/15866; https://doi.org/10.1038/sj.ejhg.5201848

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.