Support for involvement of the AHI1 locus in schizophrenia

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluati...

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Bibliographic Details
Published in:European Journal of Human Genetics
Main Authors: Ingason, Andres, Sigmundsson, Thordur, Steinberg, Stacy, Sigurdsson, Engilbert, Haraldsson, Magnus, Magnusdottir, Brynja B, Frigge, Michael L, Kong, Augustine, Gulcher, Jeffrey, Thorsteinsdottir, Unnur, Stefansson, Kari, Petursson, Hannes, Stefansson, Hreinn
Other Authors: deCODE genetics, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Nature Publishing Group 2007
Subjects:
Adaptor Proteins
Signal Transducing
Case-Control Studies
Genetic Markers
Humans
Iceland
Schizophrenia
Online Access:http://hdl.handle.net/2336/15866
https://doi.org/10.1038/sj.ejhg.5201848
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.

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