An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival

• Published in: Annals of the New York Academy of Sciences
• Main Authors: Arason, Gudmundur Johann, Bodvarsson, Sigurdur, Sigurdarson, Sigurdur Thor, Sigurdsson, Gardar, Thorgeirsson, Gudmundur, Gudmundsson, Sveinn, Kramer, Judit, Füst, Georg
• Format: Article in Journal/Newspaper
• Language: English
• Published: New York Academy of Sciences 2007
• Subjects: Adolescent; Adult; Aged; 80 and over; Aging; Complement C3; Complement C4b; Complement System Proteins; Gene Frequency; HLA-B Antigens; Health Status; Humans; Iceland; Middle Aged; Survivors; Variation (Genetics)
• Online Access: http://hdl.handle.net/2336/15445; https://doi.org/10.1196/annals.1299.091

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.