An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequenc...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences
Main Authors: Arason, Gudmundur Johann, Bodvarsson, Sigurdur, Sigurdarson, Sigurdur Thor, Sigurdsson, Gardar, Thorgeirsson, Gudmundur, Gudmundsson, Sveinn, Kramer, Judit, Füst, Georg
Format: Article in Journal/Newspaper
Language:English
Published: New York Academy of Sciences 2007
Subjects:
Adolescent
Adult
Aged
80 and over
Aging
Complement C3
Complement C4b
Complement System Proteins
Gene Frequency
HLA-B Antigens
Health Status
Humans
Iceland
Middle Aged
Survivors
Variation (Genetics)
Online Access:http://hdl.handle.net/2336/15445
https://doi.org/10.1196/annals.1299.091
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.

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