Monoclonal gammopathy: natural history studied with a retrospective approach

To access publisher full text version of this article. Please click on the hyperlink in Additional Link field The aim of this study was to examine the natural history of monoclonal gammopathy using a retrospective approach and a long observation period. Protein electrophoresis (PE) and immunofixatio...

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Bibliographic Details
Main Authors: Steingrimsdottir, Hlif, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Gudnason, Vilmundur, Ogmundsdottir, Helga M
Other Authors: Landspitali University Hospital, Department of Clinical Hematology, Reykjavik, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: Ferrata Storti Foundation 2007
Subjects:
Multiple Myeloma
Iceland/epidemiology
Disease Progression
Waldenstrom Macroglobulinemia
Precancerous Conditions
Iceland
Online Access:http://hdl.handle.net/2336/13045
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Link field The aim of this study was to examine the natural history of monoclonal gammopathy using a retrospective approach and a long observation period. Protein electrophoresis (PE) and immunofixation (IF) was performed on frozen prediagnosis serum samples from 65 multiple myeloma (MM) and 10 Waldenström's macroglobulinemia (WM) cases. Paraprotein was found in 28% and 46% of the samples from cases using PE and IF respectively. The type of paraprotein was IgA in 33.4% of cases, IgG in 57%, and IgM in 8.5%. Excluding light chain or non-secretory disease, 72 % of MM cases had a prodromal MGUS phase within 10 years of diagnosis MM and WM were preceded by MGUS in at least half of the cases, confirming the premalignant nature of this condition.

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