Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families

• Published in: American Journal of Medical Genetics
• Main Authors: Kalsi, G, Brynjolfsson, J, Butler, R, Sherrington, R, Curtis, D, Sigmundsson, T, Read, T, Murphy, P, Sharma, T, Petursson, H
• Other Authors: Department of Psychiatry, University College London Medical School, United Kingdom.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley-Liss 2011
• Subjects: Chromosomes; Human; Pair 22; Family; Genetic Linkage; Genetic Markers; Great Britain; Humans; Iceland; Lod Score; Pedigree; Schizophrenia; Long Arm
• Online Access: http://hdl.handle.net/2336/123078; https://doi.org/10.1002/ajmg.1320600407

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field A possible linkage to a genetic subtype of schizophrenia and related disorders has been reported on the long arm of chromosome 22 at q12-13. (Pulver et al., 1994: Am J Med Genet 54:36-43; Coon et al., 1994: Am J Med Genet 54:72-79; Pulver et al., 1994: Am J Med Genet 54:44-50). However formal statistical tests in a combined sample could not reject homogeneity and prove that there was a linked subgroup of families. We have studied 23 schizophrenia pedigrees to test whether some multiplex schizophrenia families may be linked to the microsatellite markers D22S274 and D22S283 which span the 22q12-13 region. Two point followed by multipoint lod and non-parametric linkage analyses under the assumption of heterogeneity provided no evidence for linkage over the relevant region.