Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field A possible linkage to a genetic subtype of schizophrenia and related disorders has been reported on the long arm of chromosome 22 at q12-13. (Pulver et al., 1994: Am J Med Genet 54:36-43; C...

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Bibliographic Details
Published in:American Journal of Medical Genetics
Main Authors: Kalsi, G, Brynjolfsson, J, Butler, R, Sherrington, R, Curtis, D, Sigmundsson, T, Read, T, Murphy, P, Sharma, T, Petursson, H
Other Authors: Department of Psychiatry, University College London Medical School, United Kingdom.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley-Liss 2011
Subjects:
Chromosomes
Human
Pair 22
Family
Genetic Linkage
Genetic Markers
Great Britain
Humans
Iceland
Lod Score
Pedigree
Schizophrenia
Long Arm
Online Access:http://hdl.handle.net/2336/123078
https://doi.org/10.1002/ajmg.1320600407
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field A possible linkage to a genetic subtype of schizophrenia and related disorders has been reported on the long arm of chromosome 22 at q12-13. (Pulver et al., 1994: Am J Med Genet 54:36-43; Coon et al., 1994: Am J Med Genet 54:72-79; Pulver et al., 1994: Am J Med Genet 54:44-50). However formal statistical tests in a combined sample could not reject homogeneity and prove that there was a linked subgroup of families. We have studied 23 schizophrenia pedigrees to test whether some multiplex schizophrenia families may be linked to the microsatellite markers D22S274 and D22S283 which span the 22q12-13 region. Two point followed by multipoint lod and non-parametric linkage analyses under the assumption of heterogeneity provided no evidence for linkage over the relevant region.

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