No evidence of linkage between schizophrenia and D3 dopamine receptor gene locus in Icelandic pedigrees

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The D3 dopamine receptor gene is an important candidate gene for schizophrenia, since--because of its almost exclusive expression in the limbic system--it combines the dopamine receptor hyp...

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Bibliographic Details
Published in:Psychiatry Research
Main Authors: Wiese, C, Lannfelt, L, Kristbjarnarson, H, Yang, L, Zoega, T, Sokoloff, P, Ivarsson, O, Schwartz, J C, Moises, H W, Helgason, T
Other Authors: Department of Psychiatry, Kiel University Hospital, Germany.
Format: Article in Journal/Newspaper
Language:English
Published: Elsiver 2011
Subjects:
Adult
Aged
80 and over
Chromosome Mapping
Female
Genetic Linkage
Humans
Iceland
Male
Middle Aged
Pedigree
Polymerase Chain Reaction
Polymorphism
Genetic
Receptors
Dopamine
Dopamine D2
Dopamine D3
Recombination
Risk Factors
Schizophrenia
Schizophrenic Psychology
Online Access:http://hdl.handle.net/2336/122646
https://doi.org/10.1016/0165-1781(93)90009-6
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field The D3 dopamine receptor gene is an important candidate gene for schizophrenia, since--because of its almost exclusive expression in the limbic system--it combines the dopamine receptor hypothesis with the limbic system hypothesis of schizophrenia. Pairwise linkage analyses were carried out between the D3 dopamine receptor gene locus (DRD3) and schizophrenia (including major depression among its pleiotropic manifestations). On the basis of these analyses, which assumed a penetrance of 0.71 and a dominant mode of inheritance, we were able to exclude the DRD3 locus with a lod score of -2.50 in four Icelandic pedigrees. The area of exclusion (lod score < -2.00) extended 1.2 centimorgans. We conclude that the genetic predisposition to schizophrenia in these pedigrees is not due to a mutation in the DRD3 locus. However, these results cannot exclude the possibility that a defect in other genes regulating the expression of the D3 dopamine receptor gene could be involved in the pathogenesis of schizophrenia or that linkage analyses in other families or population-based association studies might show a positive result.

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